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Method of non-destructively measuring biological active tissue heat parameter

A technology of living tissue and biological tissue, applied in diagnostic recording/measurement, medical science, sensor, etc., which can solve problems such as inconvenient use and operation

Inactive Publication Date: 2006-05-03
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This probe is good for thermal measurements, but not easy to use and handle

Method used

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  • Method of non-destructively measuring biological active tissue heat parameter
  • Method of non-destructively measuring biological active tissue heat parameter
  • Method of non-destructively measuring biological active tissue heat parameter

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Embodiment Construction

[0022] In a specific implementation, it is assumed that within the measured temperature range, the columnar living tissue is isotropic and its thermal parameters are constant, and it is considered that the heat of blood flowing through the cross section of the columnar living body is balanced. Under the established cylindrical coordinates, in the two-dimensional Pennes heat transfer model of the columnar biological living tissue with length L = 0.32m and radius R = 0.045m, the governing equation and boundary conditions are shown in Equation 4 and Equation 5 respectively:

[0023] ( ρc ) t ∂ T ∂ t = k [ ∂ 2 T ∂ x 2 ...

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Abstract

The invention provides a method for nondestructively measuring thermal parameters of living biological tissue, which is used for determining the thermal parameters of cylindrical living living tissue through three-point surface temperature measurement. The method includes: establishing a two-dimensional Pennes heat transfer model of a cylindrical living body tissue under cylindrical coordinates; using a row-by-row method to solve the temperature change in the cylindrical living body tissue under the interference of a step heat flow or a square wave heat flow; , analyze the correlation between the sensitivity coefficients of thermal parameters and the influence of thermal parameters on temperature changes, and optimize the selection of three measurement points; develop a measurement system for the surface temperature of biological living tissue, and collect temperature transient response data in real time; application improvement Using the Gaussian parameter estimation method, thermal parameters such as thermal conductivity, thermal diffusivity, blood perfusion rate, and volumetric heat capacity of cylindrical biological living tissue are obtained at the same time. The advantage is that it realizes convenient and simple non-destructive measurement.

Description

technical field [0001] The invention belongs to the technical field of biological living body measurement, and in particular provides a method for non-destructively measuring thermal parameters of biological living tissue, which determines the thermal conductivity, thermal diffusivity, blood perfusion rate and volumetric heat capacity of columnar biological living tissue through three-point surface temperature measurement Method for isothermal parameters. Background technique [0002] The measurement of thermal parameters of biological living tissue is the key to in-depth study of the heat transfer characteristics and mechanism of organisms and the reconstruction of tissue temperature field. However, the anisotropy of biological materials, large differences between different samples of the same type, thermal properties of tissues under various physiological states, and changes in blood perfusion rate and metabolic heat production all pose many difficulties for the measuremen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00A61B5/01
Inventor 张欣欣乐恺于帆姜泽毅冯研卉林林
Owner UNIV OF SCI & TECH BEIJING
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