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Continuously perfused heart keeping device

A preservation device and heart technology, applied in the preservation, application, and animal husbandry of human or animal bodies, can solve the problems of aggravating energy generation, myocardial cell damage, and damaging enzyme activity, so as to avoid the decline of enzyme activity and reduce the cost of preservation , the effect of reducing damage

Inactive Publication Date: 2005-12-28
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of the above method and storage device are: 1. It cannot provide the isolated heart with oxygen and nutrients necessary for myocardial metabolism; 2. It cannot regulate the internal environment of myocardial work, and the acidic metabolites generated by anaerobic metabolism of cardiomyocytes Accumulation, causing myocardial cell damage; 3. Low temperature storage damages the activity of enzymes and aggravates energy generation disorders; 4. Cannot monitor the preservation of the donor heart
Therefore, using the above preservation device, the preservation effect of the isolated heart is poor (the incidence of cardiac insufficiency after transplantation is high), and the safe preservation time is short (4 to 6 hours).

Method used

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  • Continuously perfused heart keeping device
  • Continuously perfused heart keeping device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The structure of the continuous perfusion heart preservation device in this embodiment is as follows: figure 1 As shown, it includes a heart and a preservation solution storage container 1, a membrane lung 6 provided with an air inlet pipe 8 and an air outlet pipe 9, a perfusion pump 10, a blood vessel 13 inserted on the heart and the preservation solution storage container 1, a heart and a preservation The perfusion pipe 3 in the liquid storage container 1, the heart placed and preserved liquid filter member 12, the liquid inlet pipe 11, the liquid outlet pipe 5, and the sampling pipe 4 installed in the bottom of the heart and the preserved liquid storage container 1. The liquid inlet pipe 11 is a silicone rubber tube, one end of which is connected to the heart and the storage container 1 of the preservation solution, and the other end is connected to the membrane lung 6; the liquid outlet pipe 5 is a silicone rubber tube, one end of which is connected to the membrane l...

Embodiment 2

[0032] The structure of the continuous perfusion heart preservation device in this embodiment is as follows: figure 2 As shown, the differences from Embodiment 1 are: 1. A pressure controller 14 is added, and the pressure controller is connected with the perfusion pump 10 and the perfusion tube 3 through pipe fittings. 2. The shape and structure of the heart and the preservation solution storage container 1 are as follows: figure 2 As shown, the single-layer structure rigid body made of transparent plastic and the rigid cover plate 15 made of plastic are combined. The shape of the body is a trapezoidal groove, and the combined surface of it and the membrane lung is an inclined plane. 3. The shell 17 of the membrane lung 6 is a prism formed by an inclined plane and a plane, such as figure 2 As shown, the combined surface of the shell 17 and the body of the heart and the preservation fluid storage container 1 is an inclined plane, and the combined connection method is hookin...

Embodiment 3

[0034] The structure of the continuous perfusion heart preservation device in this embodiment is as follows: image 3 As shown, the differences from Embodiment 1 are: 1. A temperature monitor 16 is added, which is installed in the heart and the storage container 1 for the preservation solution. 2. The shape and structure of the heart and the preservation solution storage container 1 are as follows: image 3 As shown, it is composed of a single-layer structure rigid body made of transparent plastic and a flexible cover 2 made of plastic film, and the body is a rectangular groove. 3. The shell 17 of the membrane lung 6 is a cube, such as image 3 shown.

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Abstract

A continuous perfusion heart preservation device, comprising a heart and a storage container for a storage solution, a membrane lung, a perfusion pump, a perfusion tube located in the heart and the storage container for a storage solution, a liquid inlet tube, a liquid outlet tube, and a sampling tube. One end of the liquid inlet pipe is connected with the heart and the preservation solution storage container, and the other end is connected with the membrane lung; one end of the liquid outlet pipe is connected with the membrane lung, and the other end is connected with the perfusion tube located in the heart and the preservation solution storage container; One end is connected with the membrane lung, and the other end is connected with the heart and the preservation solution storage container; the perfusion pump is installed in the pipeline formed by the liquid inlet tube. In this way, a closed circulatory system capable of gas exchange can be formed, so that the isolated heart (donor heart) can not only absorb oxygen and nutrients from the preservation solution, but also maintain the stability of the inner environment of the myocardium, which is beneficial to improve the isolated heart (donor heart). heart) preservation effect.

Description

1. Technical field [0001] The invention belongs to an isolated heart (donor heart) preservation device, in particular to a preservation device capable of continuously perfusing a preservation solution to an isolated heart (donor heart). 2. Background technology [0002] At present, heart transplantation has become an effective method for treating end-stage heart disease, and the preservation effect of the isolated heart (donor heart) directly affects the success rate of heart transplantation. It has been more than 30 years since the first human heart transplantation, the design of the donor heart preservation solution has been changing, but the preservation technology of the donor heart has hardly changed. "High potassium arrest, low temperature static preservation" has always been the main method of donor heart preservation. Corresponding to this method, the isolated heart (donor heart) preservation device is a plastic bag and a container containing ice cubes. The isolated ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N1/02
Inventor 杜磊
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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