Silybin injection containing cyclo dextrin or its derivatives

Abstract

The present invention features that silybin is included by cyclodextrin or its derivative so as to dissolve in water to prepare injection. The present invention solves the problem of water insoluble silybin for being suitable for intravenous injection.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a silymarin injection containing cyclodextrin or its derivatives. Background technique [0002] Milk thistle is also known as milk thistle, and its extract is silymarin. Milk thistle has been used to treat liver diseases for many years. There are many reports on silymarin research at home and abroad. In the research on silymarin, it is found that silymarin contains multiple A mixture of components, in which silibinin and silidianin are the main components, and there are also silicristion and silicristin. Studies on the pharmacological effects of silymarin have found that silymarin has obvious liver protection effects, and its effects are mainly reflected in the effects of anti-oxidative free radicals, anti-lipid peroxidation, anti-lipoxygenase, and anti-GSH wandering effects. Through these The role is to protect the liver and prevent alcohol, toxins and viruses from damaging the l...

AI Technical Summary

Problems solved by technology

It is reported in the literature that the oral bioavailability of silymarin is low, usually 30% to 40%, and individual differences are large. Although the water solubility of silymarin can be increased by making silymarin meglumine salt, the absorption amount can be appropriately increased, but due to water Silymarine meglumine will still be precipitated in the stomach, which will affect its absorption, so the preparation of milk thistle injection has important clinical significance