Database-based bioreactor design method and system

Abstract

The invention relates to the technical field of bioreactor design, in particular to a bioreactor design method and system based on a database, and the method comprises the steps: S1, extracting the design characteristics of a target reactor according to the design requirements of the target reactor; s2, searching a similar historical reactor from the database by adopting the design characteristics, and adjusting the historical reactor to generate a simulation reactor; and S3, carrying out simulation and iteration on the simulation reactor, and outputting the simulation reactor as the target reactor when the simulation reactor accords with the design index of the target reactor. The method has the beneficial effects that iteration and simulation are performed on the simulation reactor under the guidance of the historical reactor through the pre-constructed database in which the historical reactor is stored, so that a better design effect is realized, and the problem of design defects caused by design depending on artificial experience in the prior art is avoided.

Description

technical field [0001] The invention relates to the technical field of bioreactor design, in particular to a database-based bioreactor design method and system. Background technique [0002] Bioreactor refers to the use of naturally occurring microorganisms, animal cells (such as CHO cells, Vero cells, etc.) or microorganisms with special degradation ability to inoculate into liquid or solid phase, and use enzymes or organisms (such as microorganisms). The biological function of a reaction system that performs biochemical reactions in vitro. Compared with some chemical reactors, bioreactors do not require a high temperature and high pressure environment during the reaction process, so their energy consumption performance is particularly prominent. have important applications. At the same time, animal cells are used in vaccine production, such as vaccine production with Vero cells, production of antibodies and biological macromolecules, such as the production of monoclonal ...

AI Technical Summary

Problems solved by technology

[0003] In the prior art, the redesign of the bioreactor is mainly done by relying on manual experience, and it is impossible to know the designed What is the process performance of the bioreactor? It is necessary to wait for the actual test of the bioreactor to know its process performance. This method of process design based on experience has great risks, which may lead to the design of the bioreactor. After the actual test, there is a significant deviation from the expected process performance, so that it needs to be rectified or cannot be directly used in the expected cell culture process

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