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Quasi-neural electrode for accurate stimulation of cochlea nucleus

A nerve-like and electrode technology, applied in the field of implantable electrodes and nerve-like electrodes, can solve problems such as electrode stimulation current divergence, and achieve the effects of reducing neuron loss, precise stimulation, and limiting current divergence.

Pending Publication Date: 2022-08-09
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
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  • Claims
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Problems solved by technology

[0004] The purpose of the present invention is to solve the problem of stimulation current divergence in existing electrodes, by providing flexible electrode wires, implanted inside the cochlear nucleus, and setting electrode points on the electrode wires to reduce the divergence of stimulation currents

Method used

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  • Quasi-neural electrode for accurate stimulation of cochlea nucleus
  • Quasi-neural electrode for accurate stimulation of cochlea nucleus
  • Quasi-neural electrode for accurate stimulation of cochlea nucleus

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Embodiment

[0066] In this example, there are six implanted electrode wires, which are respectively implanted in the cochlear nucleus area responsible for low-frequency, mid-frequency and high-frequency sound processing, and one long and one short electrode wire is implanted in each area (see figure 1 ). Usually, the electrode point diameter of clinical products is 700μm. In this example, the outer diameter of the electrode point is 25μm. The total diameter of all strip lines does not exceed 1mm, and the total length is 150mm. The production method is as follows:

[0067] 1. Select silicon wafers (or glass) with a thickness of 300-500μm, put them into acetone, ethanol and deionized water for ultrasonic cleaning for 5 minutes, blow dry with a nitrogen gun, and dry them in an oven at 120 °C for 1-2 hours. spare;

[0068] 2. Sputtering metal Al on the cleaned silicon wafer as a sacrificial layer;

[0069] 3. On the sacrificial layer, use chemical vapor deposition to deposit 1-2μm thick Pa...

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Abstract

The invention discloses a quasi-neural electrode for accurate stimulation of cochlea nucleus, which is made of a flexible material and comprises at least one implanted electrode wire, the implanted electrode wire is provided with a plurality of electrode points, each electrode point at least comprises an outer ring electrode and a central electrode, the outer ring electrode is arranged on the periphery of the central electrode in a surrounding manner to form a concentric circle structure, and the central electrode is arranged on the outer ring electrode. And the central electrode is electrically isolated from the outer ring electrode. According to the invention, the micron-sized electrode is made of a flexible material, the size and the material of the micron-sized electrode are close to those of a target neuron, the micron-sized electrode can go deep into a cochlea core, the target neuron can be accurately stimulated, and stimulation to non-target neuron is reduced; a miniature Laplace concentric electrode structure is further designed, any two or more of the electrode arrays can form a current loop, stimulation current diffusion can be effectively inhibited, stimulation is more efficient, the cochlea core is stimulated to respond to neurons of different frequencies of sound in the deep portion more accurately and efficiently, and meanwhile the auditory reconstruction effect is improved.

Description

technical field [0001] The invention belongs to the field of medical devices and relates to an implantable electrode, in particular to a pseudo-neural electrode used for precise stimulation of the cochlear nucleus. Background technique [0002] Artificial hearing brainstem implantation is the only way to treat severe deafness with severe cochlear and / or cochlear neuropathy. The principle is to implant electrodes in the central cochlear nucleus to produce hearing. However, since the cochlear nucleus has multiple histological and functional divisions, which are mainly composed of nerve cells with different electrophysiological properties, and the distribution of neurons that respond to different frequencies of sound from the surface of the cochlear nucleus to the depths of the nucleus, all of which increase the amount of sound passing through the cochlea. Difficulty in producing meaningful hearing with nuclear surface electrical stimulation. [0003] like figure 1 As shown i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/05A61N1/36
CPCA61N1/0541A61N1/36038
Inventor 吴皓贾欢
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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