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Production and preparation process of benzethonium chloride

A kind of benzethonium chloride, the technology of preparation process, is applied in the field of preparation of benzethonium chloride, can solve the problem such as high reaction temperature, achieve the effect of good purity, few by-products, low volatility

Pending Publication Date: 2022-07-29
扬州虹光生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The production preparation method of existing benzethonium chloride comprises using p-tertoctylphenol, dichlorodiethyl ether, dimethylamine and benzyl chloride as raw material synthesis benzethonium chloride, but, in the preparation process, reaction temperature is also relatively High, there are hidden dangers in high temperature and high pressure environment

Method used

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  • Production and preparation process of benzethonium chloride

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Effect test

Embodiment

[0021] Weigh 210 grams of 4-tert-octylphenol and dissolve it in 85 grams of chloroethanol, stir and heat to about 65 ° C, and react for 4 hours, then slowly add 145 grams of (β-chloroethyl) dimethylamine, hydrochloride and 200 grams of 20% sodium hydroxide solution, after the dropwise addition is completed, slowly rise to 80 °C at a rate of 10 °C per hour, react under reflux for 6 hours, then cool and stand for stratification. Phase layer, wash the organic layer twice with ethyl acetate, and filter to obtain N,N-dimethyl-2-(2-(4-(2,4,4-trimethylpentan-2-yl)) Phenoxy)ethoxy)ethan-1-amine. It weighed 315.8 grams after drying.

[0022] Weigh 300 grams of the prepared N,N-dimethyl-2-(2-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)ethoxy)ethane-1 - The amine was dissolved in 500ml of ethyl acetate solution, 100g of benzyl chloride was added dropwise at a rate of 2 drops per second, the temperature was raised to 80°C after the dropwise addition was completed, the reaction was stopped fo...

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Abstract

The invention discloses a production and preparation process of benzethonium chloride, which comprises the following steps: a, preparing 2-(4-(2, 4, 4-trimethylpentane-2-yl) phenoxy) ethyl-1-ol by using 4-tert-octylphenol and chloroethanol as raw materials; b, preparing N, N-dimethyl-2-(2-(4-(2, 4, 4-trimethylpentane-2-yl) phenoxyl) ethyoxyl) ethyl-1-amine by taking the 2-(4-(2, 4, 4-trimethylpentane-2-yl) phenoxyl) ethyl-1-alcohol and (beta-chloroethyl) dimethylamine as raw materials, and preparing N, N-dimethyl-2-(2-(4-(2, 4, 4-trimethylpentane-2-yl) phenoxyl) ethyoxyl) ethyl-1-amine by taking the 2-(4-(2, 4, 4-trimethylpentane-2-yl) phenoxyl) ethyoxyl) ethyl-1-alcohol and (beta-chloroethyl) dimethylamine as raw materials; c, N, N-dimethyl-2-(2-(4-(2, 4, 4-trimethylpentane-2-yl) phenoxyl) ethyoxyl) ethyl-1-amine and benzyl chloride are used as raw materials, and benzethonium chloride is prepared. The 4-tert-octylphenol, the chloroethanol and the (beta-chloroethyl) dimethylamine are used as raw materials, synthesis is carried out through three steps which are all normal pressure reactions, and compared with the prior art, lower temperature is kept, the yield is higher in the synthesis process, better purity is achieved, few byproducts are produced, and excessive solid waste is not generated in the synthesis process. The used solvent is low in toxicity and volatility, VOC emission is convenient to control in the production process, and relevant national industrial policies are met.

Description

technical field [0001] The invention relates to the technical field of benzethonium chloride preparation, in particular to a production and preparation process of benzethonium chloride. Background technique [0002] Benzethonium chloride is a new type of cationic surfactant, which is easily soluble in water to form a foamy soapy water-like solution, and has been widely used as a daily chemical additive. Benzethonium chloride also has good bactericidal and antiseptic effects. As a new generation of detergents, fungicides and preservatives, it has been widely used in the field of medicine. [0003] The production and preparation method of existing benzethonium chloride comprises using p-tert-octylphenol, dichlorodiethyl ether, dimethylamine and benzyl chloride as raw materials to synthesize benzethonium chloride, but, in the preparation process, the reaction temperature is also relatively Higher, there are hidden dangers in high temperature and high pressure environment. SU...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C213/08C07C217/08
CPCC07C213/08C07C213/06C07C41/01C07C217/08C07C43/23
Inventor 吴枫赵朴叶青
Owner 扬州虹光生物科技有限公司
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