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Stacked fixed bed bioreactor and method of use thereof

An adhesive polymer, cell culture technology, applied in methods of supporting/immobilizing microorganisms, bioreactors/fermenters for specific purposes, bioreactor/fermenter combinations, etc., which can solve problems affecting the scale of the reactor, etc.

Pending Publication Date: 2022-07-12
CORNING INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such a design greatly affects the reactor scale-up in bioprocessing therapeutic manufacturing
For example, while suspension stirred tank bioreactors can be scaled up to 2,000L or 10,000L, typical packed bed bioreactors can only be scaled up to a capacity of 50L

Method used

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  • Stacked fixed bed bioreactor and method of use thereof
  • Stacked fixed bed bioreactor and method of use thereof
  • Stacked fixed bed bioreactor and method of use thereof

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Embodiment Construction

[0026] Various embodiments of the present disclosure will be discussed with reference to the accompanying drawings, which illustrate various aspects of a packed bed bioreactor system and related methods of using the same, according to non-limiting embodiments of the present disclosure. The following description is intended to provide a working description of the bioreactor system, and various aspects of the bioreactor system and method will be discussed in detail throughout this disclosure with reference to non-limiting embodiments, which in the context of the present disclosure may be mutually exchange.

[0027] The present disclosure describes modular fixed bed bioreactors and bioreactor systems having stacks of such fixed bed bioreactors. Embodiments include individual modules of a fixed bed bioreactor, as well as stacked assemblies of connected units. The use of individual packed bed modules that can be combined provides a solution that is scalable and eliminates the limi...

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Abstract

A modular and stacked cell culture system includes individual cell culture subunits having an internal chamber for containing a cell culture substrate in a cell culture space, a fluid inlet for supplying fluid to the cell culture space, and a fluid outlet for removing fluid from the chamber. The chamber is arranged for fluid to flow in from the fluid inlet, through the cell culture space, and then out through the fluid outlet. The subunit further includes an alignment feature on at least one of a top and a bottom of an individual cell culture subunit, where the alignment feature is aligned with an alignment feature of another individual cell culture subunit such that a plurality of individual cell culture subunits are stackable.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims the benefit of priority under 35 U.S.C § 120 to US Provisional Application Serial No. 62 / 941,308, filed November 27, 2019, the contents of which are hereby incorporated by reference in their entirety. technical field [0003] The present disclosure relates generally to the field of bioprocessing and, in particular, to modular and stacked packed bed bioreactors and methods of using the bioreactors for cell culture. Background technique [0004] In the bioprocessing industry, large-scale cell culture is performed for the production of hormones, enzymes, antibodies, vaccines, and cell therapy. Most cells used in bioprocessing are anchorage-dependent, meaning that cells need a surface to adhere to in order to grow and function. Traditionally, culturing of adherent cells has been performed on two-dimensional (2D) surfaces of adherent cells contained in one of a variety of container formats such as T-...

Claims

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Application Information

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IPC IPC(8): C12M3/00C12M1/12C12M1/00
CPCC12M23/44C12M25/18C12M27/22C12M29/10
Inventor V·N·戈拉尔
Owner CORNING INC
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