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Anti-irritants in cosmetic compositions

A technology of composition and cosmetics, applied in the direction of cosmetics, cosmetic preparations, drug combinations, etc., can solve the problems of not teaching gluconolactone anti-irritants, etc., and achieve the effect of reducing skin irritation and improving irritation

Inactive Publication Date: 2004-04-21
UNILEVER NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This Exuviance product does not use gluconolactone as an anti-irritant and the inserted product fact sheet does not teach that gluconolactone is an anti-irritant

Method used

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  • Anti-irritants in cosmetic compositions
  • Anti-irritants in cosmetic compositions
  • Anti-irritants in cosmetic compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] The possible anti-inflammatory effects of test compounds were assessed by their ability to inhibit IL-la-induced PGE2. IL-1α and PGE2 are well known mediators of skin inflammation. See Greaves et al., "Prostaglandins, leukotrienes, phospholipases, platelet-activating factor, and cytokinesis: A comprehensive approach to the treatment of human skin inflammation", Arch. Dermatol. Res. (1988), 280 [Supp]: S33-S41 .

[0066] Neonatal human dermal fibroblasts (paragraphs 5-9) were seeded at a density of 7500 cells per well on tissue culture treated plates (Corning-Costar, Corning, NY) in 96 wells. The medium used was Dulbecco's modified Eagle's medium (DMEM), high glucose (Gibco / Biotechnology, Gaithersburg, MD) supplemented with 2 mM L-glutamine, 10% fetal bovine serum and antibiotic and antifungal solutions (also both See Biotechnology). After 48 hours, each well was rinsed twice with 200 microliters of serum-free DMEM and the wells were dosed with 200 microliters of DMEM...

Embodiment 2

[0077] Stimulus test method

[0078] Four-exposure patch test: The objective is to compare the degree of irritation caused by repeated patch application of each test substance, keeping the test substance in contact with the skin under closed conditions. The panelist's upper outer arm was designated as the area of ​​application. A patch (25 mm Hill Top Chamber filled with 18 mm diameter Webril filler discs) was placed in place using a bandage-type dressing (Scanpor tape). Use both upper arms of the team member. Patches were applied in a balanced random order.

[0079]Patches were applied at 9:00 am on Monday and removed at 9:00 am on Tuesday (24 hour exposure). A new set of patches was applied Tuesday at 3:00 pm and removed Wednesday at 9:00 am (18 hours exposure). A third set of patches was applied on Wednesday at 3:00 pm and removed on Thursday at 9:00 am (18 hours exposure). The final set of patches was applied on Thursday at 3:00 pm and removed on Friday at 9:00 am (1...

Embodiment 3

[0101] Compositions containing the components shown in Table 4 were tested using this challenge test method. 20 subjects were tested. The results obtained are summarized in Table 4. The higher the grade sum, the lower the stimulation.

[0102] Table 4

[0103] combination

Component

Stimulus Score (4 days)

1

basic formula

68.5 a

2

Basic Formula (Composition #1) + 8% Ethanol

Acid, pH3.8

57

6

Basic Formula (Composition #1) + 8% Gluconic Acid

Lactone

100.5 a

[0104] a: Significantly lower irritation than composition 2 (2 days).

[0105] b: significantly lower than compositions 1 and 2 in irritation.

[0106] From the results in Table 4, it can be seen that gluconolactone (composition #6) significantly reduced the irritation of the base formulation which did not contain glycolic acid. This example demonstrates that the method of the present invention can be used to reduce skin irritatio...

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PUM

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Abstract

Gluconolactone or glucarolactone in cosmetic skin care compositions, as anti-irritants, to reduce skin irritation, which may be intrinsic skin irritation or irritation caused by hydroxy acids or certain retinoids.

Description

field of invention [0001] Gluconolactone and / or glucarolactone are used as anti-irritant agents in cosmetic skin care methods and compositions. Background of the invention [0002] Some ingredients used in topical products may be irritating, especially to those with "sensitive skin". [0003] For example, hydroxy acids (HA) and retinoids have been shown to provide cosmetic benefits such as improved appearance of photodamaged or naturally aged skin, skin radiance, improved treatment of age spots, and the like. Unfortunately, when used in high concentrations, they can occasionally cause skin irritation, such as reddening of the skin and a stinging sensation upon application. This irritation can be ameliorated by reducing the level of active ingredient in the composition or by reducing the penetration of the active into the skin. A serious drawback of both methods is that their efficacy is weakened. Irritation associated with HA can be reduced by inc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/00A61K8/30A61K8/34A61K8/35A61K8/36A61K8/365A61K8/37A61K8/41A61K8/44A61K8/49A61K8/60A61K8/63A61K8/67A61K8/72A61K8/73A61K8/89A61K8/99A61Q19/00A61Q19/08
CPCA61Q19/00A61K8/671A61K8/63A61K2800/75A61K8/365A61K8/60Y10S514/969A61P17/00A61K8/34A61K8/73A61K8/67A61Q17/00
Inventor R·L·维恩考夫U·桑塔纳姆L·R·帕兰克尔D·里克J·B·巴托洛尼
Owner UNILEVER NV
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