Online expired gas detection device and detection method

A detection device, a technology for exhaled breath, applied in measurement devices, instruments, scientific instruments, etc., can solve problems such as large detection errors, and achieve low cost, high stability and reproducibility, efficient extraction and enrichment and real-time detection. Effect

Pending Publication Date: 2022-06-03
ZHENGZHOU UNIV
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  • Application Information

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Problems solved by technology

Thirdly, when the content of exhaled active substances and disease markers is low, there is often a large detection error

Method used

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  • Online expired gas detection device and detection method
  • Online expired gas detection device and detection method
  • Online expired gas detection device and detection method

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Embodiment Construction

[0018] The embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings. The present embodiment is implemented on the premise of the technical solution of the present invention, and provides detailed embodiments and specific construction processes, but the protection scope of the present invention is not limited to the following described embodiment.

[0019] like Figure 1-3 As shown, the exhaled breath on-line detection device of the present invention is composed of a sample extraction part and a detection part. The detection part usually adopts a mass spectrometer M with high-throughput and high-sensitivity detection characteristics, and the sample extraction part consists of an acoustic levitation device, an exhaled air injection tube, an extraction liquid injection needle, an electrospray injector and an extraction transmitter.

[0020] Specifically, the acoustic wave suspension includes a coaxially arranged acousti...

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Abstract

The invention discloses an expired gas on-line detection device which is composed of a sample extraction part and a detection part, the sample extraction part comprises a sound wave suspension device which is provided with a sound wave emission plate and a sound wave reflection plate which are horizontally arranged, and a suspension center with balanced sound radiation pressure and liquid drop gravity is arranged between the sound wave emission plate and the sound wave reflection plate; the exhaled air injection pipe is provided with an input end for exhaling of a person to be detected and an output end opposite to the suspension center; the extraction liquid injection needle is used for injecting the extraction liquid into the sound wave suspension device drop by drop, so that the extraction liquid drops suspend in the suspension center; the electrospray injector is used for spraying electrospray to enable the extraction liquid drops to be electrified; and the extraction transmitter comprises electrode plates arranged on the two sides of the suspension center and is used for crushing the electrified extraction liquid drops and enabling the electrified extraction liquid drops to enter the detection part. The invention further discloses an expired gas online detection method using the detection device, integration of rapid, online and efficient extraction and enrichment and real-time detection of the target object in the expired gas can be achieved, and development of expired gas detection work is greatly facilitated.

Description

technical field [0001] The invention relates to the technical field of on-line detection of exhaled breath, in particular to an on-line detection device and detection method of exhaled breath. Background technique [0002] Lung cancer is the most common malignant tumor in the world and the largest cancer in my country. Lung cancer not only has a high incidence rate, it ranks first in malignant tumors, but also ranks first in mortality. It has surpassed liver cancer to become the "super killer" of cancer. If lung cancer can be detected at an early stage, the cure rate can be as high as 65%. Early detection and early treatment are the keys to improving the survival rate of lung cancer patients. Exhaled breath contains a large number of metabolic products, the types and concentrations of which are related to metabolic and pathological conditions, some of which have been shown to be biomarkers of certain diseases. Studies have shown that the concentrations of various aldehyde...

Claims

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Application Information

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IPC IPC(8): G01N27/62G01N27/68
CPCG01N27/62G01N27/68
Inventor 赵无垛罗沛如张岩皓张文芬宋琛琛罗亚珂毛健张启东欧阳钢锋张书胜
Owner ZHENGZHOU UNIV
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