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Headgear for preparing eye disease model, application of headgear and preparation method of eye disease model

A technology for eye diseases and models, applied in applications, other equipment, animal husbandry, etc., can solve problems such as low molding rate and poor model stability

Active Publication Date: 2022-06-03
成都合拓创展生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no unified standard method for making models of refractive error, which results in poor model stability; moreover, the current model making methods usually have a low molding rate

Method used

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  • Headgear for preparing eye disease model, application of headgear and preparation method of eye disease model
  • Headgear for preparing eye disease model, application of headgear and preparation method of eye disease model
  • Headgear for preparing eye disease model, application of headgear and preparation method of eye disease model

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Experimental program
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Effect test

preparation example Construction

[0053] In the headgear 100 for preparing an eye disease model provided by the present application, the mounting member 110 is fixed to the skull of the animal through the fixing portion 111, so that the orbital frame 120 can be stably fixed to the animal body, ensuring good stability when building the model; The frame 120 is provided with a vision through hole 122 for animal vision, and an eye disease simulation lens 130 is arranged in the vision through hole 122, so that the disease course progress of clinical eye disease can be simulated through the eye disease simulation lens 130, therefore, it is ensured that the construction of the animal model has a relatively high level of accuracy. Good mold rate.

[0054] In addition, in the present application, the eye disease simulating lens 130 is detachably arranged in the visual through hole 122, and it is only necessary to replace different types of eye disease simulating lenses 130 according to different types of eye diseases, a...

Embodiment

[0103] A preparation method of an eye disease model, using such as figure 1 The shown headgear 100 for preparing an eye disease model includes: disposing an eye disease simulating lens 130 with a preset light transmission standard in the vision through hole 122; fixing the fixing part 111 on the animal skull; connecting the vision through hole 122 with the eye socket of the animal On the contrary, the animal is allowed to see objects through the eye disease simulation lens 130 at the vision through hole 122; the animal is kept wearing the headgear 100 for preparing the eye disease model for a preset time.

[0104] Among them, animals are selected from 10 to 25 days after birth, and SD rats, Wistar rats, C57 mice, Kunming mice, and Balb / c mice are selected as needed. The preset wearing time is 3 to 5 weeks, 24 hours a day. wear. After wearing, the lens type and lens power can be adjusted in time according to the experimental needs to promote / reduce disease progression and dyna...

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Abstract

The invention provides a headgear for preparing an eye disease model, application of the headgear and a preparation method of the eye disease model, and belongs to the technical field of animal model construction. The head tool for preparing the eye disease model comprises a mounting piece, an eye socket frame and an eye disease simulation lens. The mounting piece comprises a fixing part and a mounting part which are connected with each other, and the fixing part is used for fixing an animal skull; the orbit frame is provided with a connecting part and an object viewing through hole, the connecting part is connected with the mounting part, and the object viewing through hole is used for animals to view objects; the eye disease simulation lens is detachably arranged in the visual through hole. The preparation method of the eye disease model is carried out by adopting the headgear for preparing the eye disease model, different types of ametropia can be prepared, the preparation of different types of eye disease models can be reliably realized, and the construction of an animal model is ensured to have relatively good stability consistency and model forming rate.

Description

technical field [0001] The present application relates to the technical field of animal model construction, in particular, to a headgear for preparing an eye disease model and its application and a method for preparing an eye disease model. Background technique [0002] Refractive error is a common type of eye disease, including myopia, hyperopia and astigmatism, which has been widely concerned by the crowd, and has also been paid more and more attention by major domestic and foreign pharmaceutical companies, ophthalmic medical device companies, and related companies in the field of optometry. In preclinical efficacy evaluation, it is necessary to prepare various animal models of refractive errors with high molding rate and strong consistency. However, at present, there is no uniform standard method for making models of refractive errors, which results in poor model stability; moreover, the current model making methods usually have a low molding rate. SUMMARY OF THE INVENT...

Claims

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Application Information

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IPC IPC(8): A01K29/00A01K67/02
CPCA01K29/00A01K67/02A01K2227/105A01K2267/03
Inventor 陈玥孙效容苏丹杨棣远张敏罗峰
Owner 成都合拓创展生物科技有限公司
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