All-optical sorting method and device for micro-nano particles

Abstract

The invention relates to the technical field of micro-nano particle separation, and discloses an all-optical sorting method and device for micro-nano particles. The all-optical sorting method of the micro-nano particles comprises the steps of irradiating the micro-nano particles above the surface of the liquid by using a linearly polarized Gaussian beam at an inclination angle theta to form an elliptical light spot on the surface of the liquid, and to form a lateral light force on the micro-nano particles, enabling the micro-nano particles to move to a balance position in the liquid along the long axis of the elliptical light spot and stop at the balance position; the inclination angle theta is an angle formed by the Gaussian beam and the normal of the surface of the liquid; the lateral light force is parallel to the long axis of the oval light spot. The invention provides a novel micro-nano particle sorting mechanism, separation is completed completely through an optical assembly, a special separation liquid or a micro-nano structure does not need to be manufactured in advance, high-precision particle size sorting is achieved, and the application prospect is considerable.

Description

technical field [0001] The present invention relates to the technical field of separation of micro-nano particles, more specifically, to a method and device for all-optical separation of micro-nano particles. Background technique [0002] Micro-nano substances such as cells, magnetic beads, silicon spheres, and polystyrene particles are widely used in biomedicine and physical chemistry as carriers or targeting targets. However, they usually contain dispersed particles of different shapes and sizes during mass production. The mixture needs to be sorted and separated in the later stage. At present, the particle size separation methods for micron-scale or even nano-scale particles or cells mainly include mechanical vibration method, density gradient centrifugation method, dialysis method and magnetic separation method. These separation methods usually use different types of particles in size, Features such as density, electrical susceptibility, and hydrodynamic properties enab...

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Problems solved by technology

In 2012, MacDonald et al. studied the motion of particles passing through a holographic optical trap array from both theoretical and experimental aspects (Journal of Optics, 2012, 14(12): 125501.). They selected proper separation between the traps, which can be Create an optical potential channel in the direction. For suspended particles mixed with two different particle sizes, the particles can be sorted in two orthogonal channels. However, this solution requires the design of a three-dimensional optical lattice, which has a complex structure and high cost.

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