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Monoterpenoid alkaloid with vasodilation activity as well as extraction method and application of monoterpenoid alkaloid

A technology of monoterpene alkaloids and vasodilation, applied in the direction of organic active ingredients, medical preparations containing active ingredients, cardiovascular system diseases, etc., to achieve the effect of high purity, good technological progress, and reasonable process design

Active Publication Date: 2022-04-26
XI AN JIAOTONG UNIV
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  • Abstract
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Problems solved by technology

[0004] However, there are few studies on the monoterpene alkaloids of chicle and their biological activities, and they have not been fully elucidated. So far, there has not been an in-depth study and vasodilatory activity of monoterpene alkaloids in chicle. Therefore, it is of great significance to discover cardiovascular and cerebrovascular drugs from sugar gum

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  • Monoterpenoid alkaloid with vasodilation activity as well as extraction method and application of monoterpenoid alkaloid
  • Monoterpenoid alkaloid with vasodilation activity as well as extraction method and application of monoterpenoid alkaloid
  • Monoterpenoid alkaloid with vasodilation activity as well as extraction method and application of monoterpenoid alkaloid

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[0026] In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0027] It should be noted that the terms "first" and "second" in the description and claims of the present invention and the above drawings are used to distinguish similar objects, but not necessarily used to describe a specific sequence or sequence. It is to be understood that the data so used are interchangeable under appropriate ...

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Abstract

The invention discloses monoterpene alkaloid with vasodilatation activity as well as an extraction method and application thereof, belongs to the technical field of natural product chemistry, and discloses a structure, separation and purification, a preparation method and structural identification of a novel monoterpene alkaloid compound 1-2 in guar gum and evaluation of the vasodilatation activity of the compound 1-2. The invention provides a lead compound for developing novel vasodilation drugs and cardiovascular drugs. The method has very important significance on comprehensive development and utilization of monoterpene alkaloids and oleanaceae plants.

Description

technical field [0001] The invention belongs to the technical field of natural product chemistry, and in particular relates to a monoterpene alkaloid with vasodilation activity and an extraction method and application thereof. Background technique [0002] Cardiovascular and cerebrovascular disease is a disease that seriously threatens human life and health, and is the main cause of human death. According to the World Health Organization (WHO) report, about 17.9 million people die of cardiovascular and cerebrovascular diseases every year. Although there are many kinds of drugs developed for the pathogenesis of cardiovascular and cerebrovascular diseases, the side effects and medication compliance of these drugs are still worrying, and it is difficult to achieve the expected therapeutic effect. Therefore, there is an urgent need to develop cardiovascular and cerebrovascular disease drugs with few side effects and clear therapeutic effects. In recent years, more and more att...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D213/80C07D213/803C07D221/04A61K31/435A61P9/08A61K31/44
CPCC07D213/80C07D213/803C07D221/04A61P9/08Y02A50/30
Inventor 詹冠群郭增军张富鑫刘欢欢张新新张卉
Owner XI AN JIAOTONG UNIV
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