Bacterial strain with function of regulating allergic constitution and application of bacterial strain
An allergy and strain technology, applied in allergic diseases, medical preparations containing active ingredients, bacteria, etc., to achieve the effect of inhibiting the aggregation of mast cells, inhibiting inflammatory reactions, and inhibiting the release of histamine
Pending Publication Date: 2022-03-08
OCEAN UNIV OF CHINA
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Problems solved by technology
Bifidobacteria are less useful than L. rhamnosus LGG for the regulation of allergic diseases, but still have efficacy
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[0024] Preparation of probiotic bacterial suspension
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Abstract
The invention discloses a bacterial strain with a function of regulating allergic physique and application thereof, and belongs to the technical field of probiotic antianaphylaxis. The LR-123 strain is screened, after the LR-123 strain is taken by a sensitization individual, the expression quantity of FoxP3 can be up-regulated, the expression quantity of STAT3 can be down-regulated, meanwhile, the LR-123 strain plays a role in protecting the intestinal tract, the form of the intestinal tract is maintained, aggregation of mast cells in the intestinal tract and release of histamine are inhibited, and contribution is made to the technical field of probiotic anti-allergy.
Description
technical field [0001] The invention belongs to the technical field of probiotic anti-allergy, and in particular relates to a bacterial strain with the function of regulating allergic constitution and application thereof. Background technique [0002] Allergy has become the number one cause of endangering the health of infants and young children, seriously endangering the growth and health of infants and young children. Infant allergy is an acute reaction disease that affects the growth and health of infants and young children caused by the inappropriate response of the immature immune system of infants to allergens in the external environment. The overreaction of the immune system to allergens can lead to abnormal reactions in the intestinal tract, skin, respiratory and nervous systems of infants, which can be life-threatening in severe cases. [0003] At present, lactic acid bacteria have been widely used in regulating infant allergies, and the main forms include two form...
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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A61K35/747A61K9/00A61P37/08C12R1/225
CPCA61K35/747A61K9/0053A61P37/08
Inventor 张兰威吴依繁韩雪公丕民蒋士龙潘健存李媛媛
Owner OCEAN UNIV OF CHINA
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