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Application of ferroptosis related gene in prognosis evaluation of diffuse large B-cell lymphoma

A prognostic assessment, lymphoma technology, applied in the field of disease prognosis and molecular biology, to achieve a good predictive effect

Active Publication Date: 2022-02-15
SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, there are few reports based on ferroptosis-related genes in DLBCL prognosis prediction

Method used

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  • Application of ferroptosis related gene in prognosis evaluation of diffuse large B-cell lymphoma
  • Application of ferroptosis related gene in prognosis evaluation of diffuse large B-cell lymphoma
  • Application of ferroptosis related gene in prognosis evaluation of diffuse large B-cell lymphoma

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Experimental program
Comparison scheme
Effect test

Embodiment

[0063] Materials and methods

[0064] The flow chart of this study is as follows figure 1 shown.

[0065] Study Population and Data Collection

[0066] Published data on DLBCL can be downloaded from the GEO database (http: / / www.NCBI.NLM.NIH.gov / GEO), (GSE87371 / GPL570, GSE10846 / GPL570 and GSE4475 / GPL96). The inclusion criteria of patients included: (a) histological diagnosis of DLBCL; (b) complete gene expression data; (c) complete survival information. Table 1 summarizes the baseline characteristics of the patients in these three cohorts. 221 patients from the GSE87371 dataset were used as the training cohort, and 388 and 159 patients from the GSE10846 and GSE4475 datasets, respectively, were used as the validation cohort.

[0067] Table 1 Clinical characteristics of DLBCL patients in this study

[0068]

[0069]

[0070] Generation of FRGs

[0071] FRG was downloaded from the FerDB website (http: / / www.Zhou nan.org / FerDB / ). The FRG list (Supplementary Table 1) was...

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Abstract

The invention provides application of ferroptosis related genes in prognosis evaluation of diffuse large B-cell lymphoma, and belongs to the technical field of disease prognosis and molecular biology. The diffuse large B-cell lymphoma prognosis model is constructed based on the ferroptosis related gene, so that the prognosis of the diffuse large B-cell lymphoma is predicted and evaluated, tests prove that the prognosis model is remarkably related to the OS of a DLBCL patient, the OS of the high-risk-value DLBCL patient is obviously shorter than that of a low-risk-value patient, and the death possibility is higher; therefore, the model has a good prediction effect, can be used for prognosis prediction of diffuse large B-cell lymphoma and auxiliary clinical decision making, and has a good practical application value.

Description

technical field [0001] The invention belongs to the technical field of disease prognosis and molecular biology, and specifically relates to the application of ferroptosis-related genes in the prognosis evaluation of diffuse large B-cell lymphoma. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Diffuse large B-cell lymphoma (DLBCL) is a malignant and aggressive tumor derived from B-lineage lymphocytes that accounts for 30–40% of non-Hodgkin's lymphomas. DLBCL is a highly heterogeneous lymphoid neoplasm with variations in gene expression profiles and alterations in genetic information. Currently, R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886G16B5/00
CPCC12Q1/6886G16B5/00C12Q2600/118C12Q2600/158
Inventor 周香香王欣胡顺凤余卓雅
Owner SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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