Application of oxaliplatin lipidosome and injections thereof in preparation of medicines for treating gastric cancer

Abstract

The invention belongs to the technical field of pharmaceutical preparations and particularly relates to application of a platinum-contained drug liposome and injections thereof in preparation of medicines for treating cancers. According to the application, by optimizing a lipid carrier and a ratio of the lipid carrier to medicines and screening the type of a stabilizer, the encapsulation efficiency of the liposome is increased, the content of related substances in the injections is lowered, and the inhibition rate on the activity of HGC and SGC-7901 gastric cancer cells is high; and the preparation disclosed by the invention can be used for improving symptoms such as listlessness of a rat suffering from a tumor, inhibiting the weight of the tumor in the rat, lowering the expression of Bcl-2 and VEGF in the tumor of the rat and improving the expression of Bax in the tumor of the rat.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to the application of oxaliplatin liposome and its injection in the preparation of drugs for treating gastric cancer. Background technique [0002] At present, platinum-based chemotherapy drugs are mainly divided into three categories: first-generation cisplatin, second-generation carboplatin, nedaplatin, and cycloplatin, third-generation oxaliplatin, and lobaplatin. [0003] Oxaliplatin is the third-generation platinum anticancer drug, which is a platinum compound of diaminocyclohexane, that is, the amino group of cisplatin is replaced by a 1,2-diaminocyclohexane group. It has the same effect as other platinum-based drugs, that is, DNA is the target site of action, and platinum atoms form cross-links with DNA to antagonize its replication and transcription. [0004] CN 103181898A discloses a kind of oxaliplatin liposome and application thereof, desc...

AI Technical Summary

Problems solved by technology

[0006] Aiming at the deficiencies in the prior art, the present invention provides a platinum-containing drug liposome, which solves the problem of low encapsulation efficiency and related substance content of platinum-containing drug liposomes by optimizing drug carriers, stabilizers, buffers, etc. High question that improves the effect of oxaliplatin in the treatment of gastric cancer

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