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Self-expanding microsphere for lacrimal sac expansion and preparation method thereof

A lacrimal sac expansion and self-expansion technology, applied in ophthalmic surgery, ophthalmic treatment, etc., can solve the problems of lacrimal sac blockage, low operation success rate, poor formation of nasal lacrimal sac anastomosis, etc. capacitive effect

Pending Publication Date: 2021-12-28
THE EYE HOSPITAL OF WENZHOU MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For patients with small lacrimal sac type, the lacrimal sac is more likely to be re-blocked due to fibrous hyperplasia, granulation tissue or scar, and the success rate of the operation is still low.

Method used

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  • Self-expanding microsphere for lacrimal sac expansion and preparation method thereof
  • Self-expanding microsphere for lacrimal sac expansion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 1.624 grams of sodium hydroxide in a sealed three-necked flask, add 9.8 milliliters of deionized water, then add 4 milliliters of acrylic acid solution containing 30% by mass fraction, continue feeding nitrogen and stir evenly, then add 0.2 grams of silk fibroin, Then add 1.36 ml of 0.1 mol / L N,N-methylene-bisacrylamide and 0.78 ml of 0.1 mol / L potassium persulfate, stir well, inject the mixed liquid into the mold, and let it stand for 30 minutes for defoaming , the mold is sealed and placed in a 70°C constant temperature box for 72 hours, and then demolded after natural cooling. The obtained microspheres are washed by water absorption and swelling for 4 days, and then dried at a constant temperature of 50°C to obtain self-expanding microspheres.

Embodiment 2

[0026] Under the condition of airtight and nitrogen flow, dissolve 0.1g initiator 4,4'-azo(4-cyanovaleric acid) in 6ml vinylpyrrolidone, add 10ml methyl methacrylate in turn, stir well and inject into the mold , let it stand for 30 minutes to remove air bubbles, seal the mold and place it in an incubator, seal the mold and place it in a 70°C incubator for 72 hours, let it cool naturally and then demould, the obtained microspheres are washed by water absorption for 4 days, and then subjected to Self-expanding microspheres can be obtained by drying at a constant temperature of 50°C.

[0027] Polymerization reaction process of the present invention is in following mold ( figure 2 ), the mold consists of two molds with connected hemispherical grooves, and the depth of the hemispherical grooves is adjustable from 2.5mm to 5mm. When in use, the two molds are put together and fixed, and the reaction solution is injected into the spherical cavity of the mold from the feed port at th...

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Abstract

The invention discloses a self-expanding microsphere for lacrimal sac expansion and a preparation method thereof. According to the skin expansion principle, the self-expanding microspheres are implanted into the lacrimal sac in an injection mode in the early stage of an operation, the microspheres absorb water in the lacrimal sac to expand and maintain the expansion state for a certain time, the lacrimal sac is expanded, and after the size of the lacrimal sac meets the operation requirement, a lacrimal sac and nasal cavity anastomosis operation under an endoscope is carried out, meanwhile, the microspheres in the lacrimal sac are taken out, and the self-expanding microspheres have good biocompatibility and certain mechanical property, can expand to 5 mm or above after absorbing water in the lacrimal sac and maintain the expansion state for a certain time, so that the effect of expanding the horizontal distance of the lacrimal sac is achieved.

Description

technical field [0001] The invention relates to the technical field of dacryocystorhinostomy, in particular to a self-expanding microsphere for lacrimal sac expansion and a preparation method thereof. Background technique [0002] Chronic dacryocystitis is one of the more common clinical eye diseases. Endoscopic dacryocystorhinostomy has become the first choice for the treatment of chronic dacryocystitis because of its high success rate and no facial scars. Endoscopic dacryocystorhinostomy requires longitudinal incision of the lacrimal sac and anastomosis of the nasal mucosa on both sides. For patients with small lacrimal sacs, the success rate of the operation is still low. The reason is that the lacrimal sacs of small lacrimal sacs Small length. Therefore, it is necessary to enlarge the size of the lacrimal sac in the early stage of the operation to ensure the success rate of the subsequent operation. However, there are currently no corresponding products for dilating th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F289/00C08F220/06C08F222/38C08F220/14C08F226/10A61F9/00A61F9/007
CPCC08F289/00C08F220/14A61F9/007A61F9/0008C08F220/06C08F222/385C08F226/10
Inventor 南开辉涂云海王冬梅
Owner THE EYE HOSPITAL OF WENZHOU MEDICAL UNIV
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