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Application of pyrroloquinoline quinone in prevention and/or treatment of female reproductive dysfunction

A pyrroloquinoline quinone, reproductive function technology, applied in the field of medicine, can solve problems such as no proof, and achieve the effect of high application value

Pending Publication Date: 2021-12-21
CHANGZHOU MATERNAL & CHILD HEALTH CARE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether PQQ supplementation can improve follicle number and egg quality, thereby enhancing fertility, has not been proven

Method used

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  • Application of pyrroloquinoline quinone in prevention and/or treatment of female reproductive dysfunction
  • Application of pyrroloquinoline quinone in prevention and/or treatment of female reproductive dysfunction
  • Application of pyrroloquinoline quinone in prevention and/or treatment of female reproductive dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0039] 1) Raising of experimental animals: preparing 8-week-old C57 / bl6 female mice as experimental mice and feeding them;

[0040] 2) Establishment of mouse model with reduced follicle quantity and quality and PQQ treatment: 8-week-old female mice were intraperitoneally injected with cyclophosphamide 120 mg / kg and 10 mg / kg busulfan; both cyclophosphamide and busulfan were first dissolved in DMSO , then diluted with normal saline to the final concentration, 10ul drug per gram of mice; 8-week-old female mice were randomly divided into 3 groups, that is, the normal control group: simple injection without drug solvent, Con, modeling group O and given PQQ-supplemented model-making group OP group; the OP group was supplemented with PQQ diet one week before model-making; mouse feed containing 5 mg / kg of PQQ;

[0041] 3) Mating experiment A female mouse was mated with a sexually mature male mouse in a cage, and the observation time was 2 months; the number of pups born to the mice wa...

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Abstract

The invention discloses an application of pyrroloquinoline quinone (PQQ) in prevention and / or treatment of female reproductive dysfunction. Research results of the invention show that supplement of pyrroloquinoline quinone can significantly improve follicle quantity and quality and reduce fertility of model mice. According to the invention, pyrroloquinoline quinone is used for treating reproductive function reduction caused by quantity reduction or quality reduction of follicles for the first time, a relatively ideal treatment effect is achieved, a new prevention and treatment choice is provided for clinical application and treatment of female reproductive dysfunction, and the pyrroloquinoline quinone has extremely high application value.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to the use of pyrroloquinoline quinone or a salt thereof in the preparation of medicines for preventing and / or treating female reproductive dysfunction or improving female reproductive function. Background technique [0002] According to statistics, around the world, about 15% of all couples of childbearing age have infertility problems, and about half of them are female factors. In causing female infertility, a considerable part of the reason is the decline in the number and quality of female eggs. With the full opening of my country's fertility policy, the number of elderly women who need to conceive has increased dramatically. Older women (greater than or equal to 35 years old) not only decline in the number of follicles but also in the quality of eggs, and their natural conception rate is significantly reduced. However, in clinical application, there is no effective drug tha...

Claims

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Application Information

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IPC IPC(8): A61K31/4745A61P15/00A61P15/08A23L33/00
CPCA61K31/4745A61P15/00A61P15/08A23L33/00A23V2002/00A23V2200/30
Inventor 戴秀亮陈莉苗登顺
Owner CHANGZHOU MATERNAL & CHILD HEALTH CARE HOSPITAL
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