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Gradient elastic deformation differential drug release composite dressing and preparation method thereof

A technology of elastic deformation and elastic deformation rate, which is applied in the fields of pharmaceutical formulation, medical science, drug delivery, etc. It can solve the problems of uncontrollable drug release and inability to achieve wound treatment, so as to improve practicability, use comfort and high production efficiency , The effect of simple preparation method

Active Publication Date: 2021-12-03
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dressing prepared by this patent is made by directly adding the drug into the spinning solution, and then electrospinning. The drug is evenly dispersed inside the fiber and released in the wound by diffusion, which cannot be controlled according to the stretching degree of the wound. The drug is released, so that the timely and effective treatment of the wound by the drug cannot be achieved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A method of preparation of differential interpretation composite dressings of gradient elastic deformation, the specific steps are as follows:

[0046] (1) Weaving gradient elastic deformation fabric:

[0047] (1.1) Designing a fabric structure: The gradient elastic deformation fabric is considered a planar structure, the plane consists of concentric No. III regions, the first II region, and the i-th region; the first point is the starting point in the edge line of the first III region. The outer offset 1cm is formed, the inner edge of the first II region and the edge common line of the first III region; the first region is from the outer edge line of the first II region to 1 cm, the inner edge of the first region is The outer edge of the II area common line;

[0048] The tissue structure of the fabric is: the II region is the weft clutch; the term II is 1 + 1 ripped tissue; the III region is 2 + 2 ribs;

[0049] The maximum elastic deformation ratio of the fabric correspon...

Embodiment 2

[0062] A method of preparation of differential interpretation composite dressings of gradient elastic deformation, the specific steps are as follows:

[0063] (1) Weaving gradient elastic deformation fabric:

[0064] (1.1) Designing a fabric structure: The gradient elastic deformation fabric is considered a planar structure, the plane consists of concentric No. III regions, the first II region, and the i-th region; the first point is the starting point in the edge line of the first III region. External shift 2 cm formation, the inner edge of the first II region and the edge of the first III region; the first region is formed outwardly from the outer edge line of the first II region to form 2 cm, the inner edge of the i-th region and the first The outer edge of the II area common line;

[0065] The tissue structure of the fabric is: 1 + 1 rip tissue in the iii region; the term II is 1 + 1 ripped tissue; the III area is 1 + 1 rip tissue;

[0066] The maximum elastic deformation rati...

Embodiment 3

[0079] A method of preparing a composite elastically deformable dressing gradient differential release, the following steps:

[0080] (1) a woven fabric the elastic deformation gradient:

[0081] (1.1) designed fabric structure: gradient considered elastically deformable textile planar structure, said first plane by a concentric region III, II, I, and the region constituting the region; the region II is an edge line as the starting point of the region III 2cm forming outer offsets, the inner edge of the edge region II III region of collinear; I, an outer edge line region is the region II starting 1.5cm formed outwardly offset inner edges of the first region and the I an outer edge of the region II collinear;

[0082] Structure of the fabric: the region I weft plain stitch; Ⅱ region of 1 + 1 rib stitch; second region Ⅲ rib structure 2 + 2;

[0083] Region Part III, II, I, and the region corresponding to the region of the fabric the maximum elastic deformation rates were 70%, 32% an...

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Abstract

The invention relates to a gradient elastic deformation differential drug release composite dressing and a preparation method thereof. The gradient elastic deformation differential drug release composite dressing comprises gradient elastic deformation fabric and drug-loading hydrogel; the gradient elastic deformation fabric is regarded as a plane structure, and the plane is composed of a third area, a second area and a first area which are concentric; the gradient elastic deformation in the gradient elastic deformation fabric refers to that the maximum elastic deformation rates of the fabric corresponding to the third area, the second area and the first area are sequentially reduced, and the maximum elastic deformation rate of the fabric corresponding to the third area is greater than the maximum deformation rate of the joint skin; and the elasticity modulus of the fabric corresponding to the third area, the second area and the first area is sequentially increased. The drug-loaded hydrogel is combined with the gradient elastic deformation fabric and is positioned in the third area and the second area of the gradient elastic deformation fabric; and the maximum elastic deformation rate of the drug-loaded hydrogel is greater than the maximum deformation rate of the joint skin. The dressing prepared by compounding the hydrogel and the fabric can generate a differential drug release effect according to the tearing degree of a wound.

Description

Technical field [0001] The present invention belongs to the technical field of biological material, compounded with a gradient directed differentiation release elastically deformable dressing preparation thereof. Background technique [0002] Skin damage is one of the common diseases in humans, will not only cause damage to the patient's bodily functions, but also extremely vulnerable to external environment infection, resulting in further deterioration of the wound. Medical dressing material is commonly used to treat skin lesions. But regular exercise for the joints of the knee, wrist, shoulder, elbow and fingers, etc., the traditional wound dressings can not meet their basic needs behavior. [0003] Currently, a material for the joint of the wound site to the main medical elastic bandage, the basic functions of the joints and the fixed protective effect. But medical elastic bandage for the wound without active treatment, not solid bandage off phenomenon will occur, the bandage ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L15/46A61L15/42A61L15/26A61L15/28C08F220/56C08F222/38
CPCA61L15/44A61L15/46A61L15/42A61L15/26A61L15/28C08F220/56A61L2300/402A61L2300/404A61L2300/602A61L2400/12C08L79/04C08L5/16C08L1/02C08F222/385
Inventor 高晶宋子钰王璐
Owner DONGHUA UNIV
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