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System and method for mapping genetic structure of Alzheimer's disease hemibrain asymmetry

A technology of genetic structure and hemi-brain of silent disease, applied in the field of brain imaging genetic structure mapping, can solve the genetic research method of hemi-brain asymmetry in AD patients is single, lacks complete mapping, and hinders the genetic origin and formation mechanism of abnormal asymmetry And other issues

Active Publication Date: 2022-05-06
SHANDONG JIANZHU UNIV
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Problems solved by technology

[0004] At present, the genetic research on hemibrain asymmetry in AD patients based on magnetic resonance imaging mainly focuses on the structural phenotypes of the gray matter regions of the brain (cortical volume, cortical thickness, surface area, etc.), ignoring the influence of genes on brain connection characteristics, and on The genetic research method of hemibrain asymmetry in AD patients is relatively simple, and the genetic analysis of hemibrain asymmetry in AD patients has not been carried out from multiple dimensions. The complete mapping of the genetic structure of AD patients hinders the exploration of the genetic origin and formation mechanism of the abnormal asymmetry of brain connectivity in AD patients

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  • System and method for mapping genetic structure of Alzheimer's disease hemibrain asymmetry
  • System and method for mapping genetic structure of Alzheimer's disease hemibrain asymmetry

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Embodiment 1

[0037] refer to figure 1 , the present embodiment provides a genetic structure drawing system for Alzheimer's disease hemibrain asymmetry, which includes:

[0038] (1) Asymmetric brain connection extraction module, which is used to extract abnormal asymmetric brain connections based on the hemi-brain functional connectivity and hemi-brain white matter connections in the multimodal magnetic resonance images of the subjects.

[0039] In the specific implementation, the subjects were obtained from international public databases such as the Alzheimer's Disease Neuroimaging Initiative (ADNI). Multimodal magnetic resonance images included sMRI images, fMRI images and dMRI images of the subjects.

[0040] In one or more embodiments, the genetic structure mapping system for Alzheimer's disease hemibrain asymmetry further includes:

[0041] The image preprocessing module is used for preprocessing the multimodal magnetic resonance images of the subjects.

[0042] Among them, the prep...

Embodiment 2

[0065] refer to figure 2 , the present embodiment provides a genetic structure drawing method for Alzheimer's disease hemibrain asymmetry, which includes:

[0066] Step 1: Based on the hemi-brain functional connectivity and hemi-brain white matter connectivity in the multi-modal magnetic resonance images of the subjects, extract abnormal asymmetric brain connections;

[0067] Step 2: Obtain the whole genome sequencing data of the subjects and perform quality control on single nucleotide polymorphisms;

[0068] Step 3: Estimate the hemispheric difference in the heritability of the connections in the left and right hemispheres, the heritability of the asymmetry coefficient, and the genetic correlation of the brain connections in the left and right hemispheres based on the abnormal asymmetry of the brain connections and the quality-controlled whole-genome sequencing data, and determine Abnormal genetic effects in AD patients;

[0069] Step 4: Based on the abnormal genetic effe...

Embodiment 3

[0075] This embodiment provides a computer-readable storage medium, on which a computer program is stored, and when the program is executed by a processor, the method for drawing the genetic structure of Alzheimer's disease hemibrain asymmetry as described in the second embodiment is realized in the steps.

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Abstract

The invention provides a genetic structure drawing system and method for Alzheimer's disease hemibrain asymmetry. Among them, the system includes an asymmetric brain connection extraction module, which is used to extract abnormal asymmetric brain connections based on the hemi-brain functional connection and hemi-brain white matter connection in the multi-modal magnetic resonance images of the subjects; the genetic data processing module uses To obtain the whole genome sequencing data of the subjects and perform quality control on single nucleotide polymorphisms; the abnormal genetic effect determination module is used to estimate the hemispheric difference of the heritability of the connection in the left and right hemispheres, the heritability of the asymmetry coefficient and the left and right Genetic correlation of hemispheric brain connections, to determine the genetic effects of abnormalities in AD patients; genetic structure mapping module, used to project estimated heritability and genetic correlations to connections based on abnormal genetic effects and quality-controlled whole-genome sequencing data brain regions and average the heritability of each brain region to map the genetic architecture of abnormal brain asymmetries.

Description

technical field [0001] The invention belongs to the field of brain imaging genetic structure drawing, and in particular relates to a genetic structure drawing system and method for Alzheimer's disease hemibrain asymmetry. Background technique [0002] The statements in this section merely provide background information related to the present invention and do not necessarily constitute prior art. [0003] Magnetic resonance imaging provides technical means for exploring the asymmetry of the human brain and its genetic mechanism. In recent years, researchers have gradually realized the importance of characterizing brain connection patterns for understanding the asymmetry of the hemibrain in patients with Alzheimer's disease (AD). From the perspective of the circuit, we can deeply explore the differences in the left and right hemispheres of the brain connection patterns of AD patients, thus providing a new perspective for understanding brain lateralization. [0004] At presen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B20/40G06T7/11G06T7/00
CPCG16B20/40G06T7/11G06T7/0012G06T2207/10088G06T2207/30016
Inventor 魏珑刘振栋郝凡昌袭肖明
Owner SHANDONG JIANZHU UNIV
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