A hypertonic seawater nasal spray

A sprayer and seawater technology, applied in the field of medical devices, can solve problems such as long-term uninterrupted use, frequent use, and mucosal atrophy, so as to relieve nasal edema, improve use effect, and avoid damage

Active Publication Date: 2022-04-22
GUANGZHOU LINGJIE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The spray liquid in the hypertonic seawater nasal sprayer provided by the present invention has no stimulating effect on the nasal mucosa after being sprayed, and has no cilia toxicity, can effectively avoid damage to the nasal mucosa caused by long-term use, and greatly improves the safety of product use. The spray liquid in the existing hypertonic seawater nasal sprayer has obvious stimulating effect when flushing the nasal cavity, and cannot be used frequently, especially for long-term uninterrupted use, which may easily cause technical problems such as mucosal atrophy with long-term use

Method used

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  • A hypertonic seawater nasal spray

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1, a kind of hypertonic seawater nasal cavity sprayer

[0025] The hypertonic seawater nasal sprayer consists of a spray tank, a nozzle and a nozzle cover, and the spray tank contains a spray liquid, and the spray liquid includes the following components and their mass percentages: 0.8% sodium bicarbonate, 2% sea salt, glycerin 0.5%, protective agent 0.5%, adhesive agent 0.3%, essence 0.003%, purified water 95.897%; the protective agent is composed of pullulan and trehalose in a mass ratio of 1:4; the adhesive agent consists of Bohm 941 and polyvinyl alcohol 1788 are composed at a mass ratio of 1:8.

[0026] The preparation method of described spray liquid is:

[0027] S1 Take sea salt, add purified water 7 times the mass of sea salt, stir evenly, add activated carbon, heat to boiling to obtain sea water;

[0028] S2 first coarsely filters the seawater obtained in step S1 with a microporous membrane with a pore size of 0.45 μm, then filters again with a mic...

Embodiment 2

[0030] Embodiment 2, a kind of hypertonic seawater nasal cavity sprayer

[0031] The hypertonic seawater nasal sprayer consists of a spray tank, a nozzle and a nozzle cover. The spray tank contains a spray liquid, and the spray liquid includes the following components and their mass percentages: 1.6% sodium bicarbonate, 2.5% sea salt, glycerin 1%, protective agent 1.5%, adhesive agent 0.6%, essence 0.005%, purified water 92.795%; the protective agent is composed of pullulan and trehalose in a mass ratio of 1:6; the adhesive agent consists of Bohm 941 and polyvinyl alcohol 1788 are composed at a mass ratio of 3:5.

[0032] The preparation method of described spray liquid is:

[0033] S1 Take sea salt, add purified water 10 times the mass of sea salt, stir evenly, add activated carbon, heat to boiling to obtain sea water;

[0034] S2 first coarsely filters the seawater obtained in step S1 with a microporous membrane with a pore size of 0.45 μm, then filters again with a microp...

Embodiment 3

[0036] Embodiment 3, a kind of hypertonic seawater nasal cavity sprayer

[0037] The hypertonic seawater nasal sprayer consists of a spray tank, a nozzle and a nozzle cover. The spray tank contains a spray liquid, and the spray liquid includes the following components and their mass percentages: 1.2% sodium bicarbonate, 2.3% sea salt, Glycerin 0.8%, protective agent 1%, adhesive agent 0.5%, essence 0.004%, purified water 94.196%; described protective agent is made up of pullulan and trehalose by mass ratio 1:5; described adhesive agent consists of Carbomer 941 and polyvinyl alcohol 1788 are composed at a mass ratio of 2:7.

[0038] The preparation method of described spray liquid is:

[0039] S1 Take sea salt, add purified water with 8 times the mass of sea salt, stir evenly, add activated carbon, heat to boiling to obtain sea water;

[0040] S2 first coarsely filters the seawater obtained in step S1 with a microporous membrane with a pore size of 0.45 μm, then filters again...

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PUM

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Abstract

The invention belongs to the technical field of medical devices, and in particular relates to a hypertonic seawater nasal cavity sprayer. The hypertonic seawater nasal cavity sprayer of the present invention is composed of a spray tank, a nozzle and a nozzle cover. The spray tank contains a spray liquid, and the spray liquid includes the following components and their mass percentages: sodium bicarbonate 0.8-1.6%, sea salt 2- 2.5%, glycerin 0.5‑1%, protective agent 0.5‑1.5%, adhesive 0.3‑0.6%, essence 0.003‑0.005%, purified water 92.795‑95.897%. The spray liquid in the hypertonic seawater nasal sprayer of the present invention has no stimulating effect on the nasal mucosa after being sprayed, has no cilia toxicity, can effectively avoid damage to the nasal cavity mucosa caused by long-term use, and greatly improves the safety of product use.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a hypertonic seawater nasal cavity sprayer. Background technique [0002] At present, air pollution is relatively serious, which has a great impact on people's nasal cavity health, and the number of people with rhinitis and other problems is gradually increasing. Rhinitis is an inflammatory disease of the nasal cavity, which is the inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases. The main pathological changes of rhinitis are congestion, swelling, exudation, hyperplasia, atrophy or necrosis of nasal mucosa. Rhinitis is a common and frequently-occurring disease, clinically manifested as nasal congestion, runny nose, decreased sense of smell and other symptoms, which brings inconvenience to work and life. The current common treatment methods for rhinitis include intran...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/14A61K9/12A61K47/32A61M11/00A61P11/02A61K31/047A61K31/7016A61K31/715A61K33/00
CPCA61K33/14A61K33/00A61K31/7016A61K31/715A61K31/047A61K47/32A61K9/0043A61K9/12A61P11/02A61M11/00A61K2300/00
Inventor 陈卫平
Owner GUANGZHOU LINGJIE PHARMA
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