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Composition for treating hair loss or promoting hair growth comprising growth factor

A technology for hair growth and growth factors, which can be used in medical preparations containing active ingredients, hair care, drug combinations, etc., and can solve problems such as low probability of success, expensive transplantation methods, and pain.

Pending Publication Date: 2021-11-16
MEDICOSBIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, this transplantation method is expensive, time-consuming and painful, and has a relatively low probability of success

Method used

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  • Composition for treating hair loss or promoting hair growth comprising growth factor
  • Composition for treating hair loss or promoting hair growth comprising growth factor
  • Composition for treating hair loss or promoting hair growth comprising growth factor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1 Cell scratch assay using growth factors

[0067] Confirm whether cell scratches are cured by treatment with growth factors (VEGF, FGFα, FGFβ, TGF-β, IGF, KGF, and SCF).

[0068] NIH3T3 cells used as fibroblasts (ATCC CRL-1658 TM ), and when the cells were in 5% CO 2 (Thermo Fisher BB15) in DMEM+bovine serum+pen-strep (antibiotic) medium (containing 10% serum, 100-fold concentration of penicillin-streptomycin added at 1% of the total volume) to 80% or more When high, use a pipette tip to scrape.

[0069] After scraping, the cells were washed twice with PBS buffer, and then 10 mL of the medium was added thereto. Regarding the medium added, for the positive control group, growth medium (DMEM+bovine serum+pen-strep) was added, for the negative control group, a medium with only antibiotic pen-strep added to DMEM was used, and for the experimental group, a medium containing 0.0001% of each of VEGF, FGFα, FGFβ, TGF-β, IGF, KGF and SCF growth factors in DMEM+pen-s...

Embodiment 2

[0080] Confirmation of hair growth effect in the hair loss mouse model of embodiment 2

[0081] In order to completely depilate the backs of eight 5-week-old mice (400-500 g, Sprague-Dawley type), the hairs were shaved, and 20-30 g of mouse removal cream (Veet) was applied to each After 5 minutes, the mouse depilatory cream was wiped off to completely remove the hair. A mouse model of hair loss was generated by applying 40 mg testosterone / 2 g gel / mouse to the area from which hair was removed twice a day, morning and evening, for 2 weeks.

[0082] A base serum (hair tonic from Medicos Biotech, Table 2) was mixed with growth factors (VEGF, FGFα, FGFβ, TGF-β, IGF, KGF and SCF) and / or silk protein as indicated in Table 1 below. Add together and then apply the serum at 10ml / mouse / day to the depilated area of ​​each mouse for 1 week.

[0083] [Table 1]

[0084] Group Application components control group Essential Serum 2.5% p.p. 2.5% serum 1.5ppm ...

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Abstract

The present invention is related to a composition for promoting hair growth or inhibiting hair loss comprising a growth factor selected from the group consisting of VEGF, FGF[alpha], FGF[beta], TGF-[beta], IGF, KGF, and SCF, as an active ingredient, according to the present invention, there is an effect of promoting hair growth and preventing hair loss by regulating the hair cycle of patients with hair loss, without causing side effects such as skin irritation and the like.

Description

technical field [0001] The present invention relates to a composition for treating alopecia or promoting hair growth comprising a growth factor, more particularly, to a composition comprising a growth factor selected from the group consisting of VEGF, fibroblast growth factor alpha (FGF alpha), FGF beta, TGF-beta, IGF, A composition for promoting hair growth or inhibiting hair loss with growth factors of KGF and SCF as active ingredients. Background technique [0002] Hair plays the role of protecting the scalp from UV rays and external stimuli and plays an important role in aesthetics. Hair loss afflicts both men and some women, and the number of sufferers of hair loss is increasing in modern society due to environmental pollution, stress and poor work-life balance. The most common type of hair loss in men is male pattern baldness or alopecia. In the case of general hair loss, hair loss occurs gradually over several years, most notably starting at the crown of the head an...

Claims

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Application Information

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IPC IPC(8): A61K38/30A61P17/14A61K8/64A61Q7/00A61K38/18A61K38/19A61K38/17
CPCA61K38/30A61K38/1866A61K38/1825A61K38/1841A61K38/18A61K38/19A61K38/1767A61P17/14A61K8/64A61Q7/00A61K35/646A61K2300/00A61K8/042A61K8/65
Inventor 柳元敏郑汉娜罗德铉
Owner MEDICOSBIOTECH INC
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