A kind of betaine salicylic acid co-crystal and preparation method and application thereof

A technology of salicylic acid and betaine, which is applied in the field of cosmetics and medicine, can solve skin and eye irritation problems, achieve the effects of reducing allergies, adjustable particle size, and reducing irritation

Active Publication Date: 2022-07-05
SHENZHEN SHINESKY BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But betaine salicylate has certain irritation, which can cause irritation to skin and eyes. Therefore, the application of betaine and salicylic acid in medicine and cosmetics needs to be improved

Method used

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  • A kind of betaine salicylic acid co-crystal and preparation method and application thereof
  • A kind of betaine salicylic acid co-crystal and preparation method and application thereof
  • A kind of betaine salicylic acid co-crystal and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0034] The preparation method of a betaine salicylic acid co-crystal provided by the invention comprises the following steps:

[0035] S1 adds solvent, betaine, salicylic acid in the autoclave, adds solvent and betaine and salicylic acid in the autoclave, stirs under the first pressure and the first temperature, forms the suspension of betaine and salicylic acid liquid.

[0036] Specifically, the solvent can be liquid CO 2 , petroleum ether and ethyl acetate. Among them, liquid CO is preferred 2 , liquid CO 2 It is non-toxic, non-flammable and affordable. The molar ratio of betaine to salicylic acid is 1:1, and the solid-liquid ratio of the sum of betaine+salicylic acid to solvent is 1:4-1:6 (kg:L). The autoclave refers to a reactor operated under high pressure. The pressure of the autoclave is set to 10-30MPa, preferably 20MPa; the temperature is set to 110-130°C, preferably 115°C; the stirring speed is 600-750r / min, preferably is 700r / min; the stirring time is 1-8h, pr...

Embodiment 1

[0045] A preparation method of betaine salicylic acid co-crystal:

[0046] S1 adds liquid CO to the autoclave 2 , betaine, salicylic acid, wherein the molar ratio of betaine and salicylic acid is 1:1, and the sum of betaine+salicylic acid and the solid-liquid ratio of solvent are 1:5 (kg:L). The pressure of the autoclave was set to 20MPa, the temperature was set to 115°C, the stirring speed was 700r / min, and stirred for 4h to form a suspension of betaine and salicylic acid;

[0047] S2 pumps the suspension to the high-pressure homogenizer by the high-pressure pump, passes through the homogenizing valve, and the pressure of the homogenizing valve is set to 800bar;

[0048] S3 decompresses the receiving chamber of the homogenizer to normal pressure at normal temperature to make the liquid CO 2 Volatile to obtain betaine salicylic acid co-crystal.

[0049] The molecular structure of betaine-salicylic acid co-crystal is as follows figure 1 shown, the molecular formula is C 12...

Embodiment 2

[0197] The difference from Example 1 is that the pressure of the homogenization valve in S2 is set to 600 bar. The single crystal data and hydrogen spectrum data of the betaine-salicylic acid co-crystal tested were the same as in Example 1, and the purity was over 98%.

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Abstract

The invention provides a betaine salicylic acid co-crystal and a preparation method and application thereof, and relates to the technical fields of medicine and cosmetics. A betaine-salicylic acid co-crystal, the betaine-salicylic acid co-crystal is orthorhombic, the space group is Pbca, the unit cell parameters are α=β=γ=90°, Z=8, and the unit cell volume The betaine salicylic acid co-crystal provided by the invention can improve the irritation problem of betaine salicylate.

Description

technical field [0001] The invention relates to the technical fields of medicine and cosmetics, in particular to a betaine salicylic acid co-crystal and a preparation method and application thereof. Background technique [0002] Beta-hydroxy acids (BHAs) in salicylic acid are similar to alpha-hydroxy acids (AHAs) and have the function of accelerating the exfoliation of scaly keratinocytes. Salicylic acid is an aromatic beta-hydroxy acid, and its efficacy in skin care products It has already been fully recognized by people. In the field of medicine, salicylic acid can be used to treat acne through topical application; in the field of cosmetics, it can improve fine lines and wrinkles caused by aging of the internal functions of the body, as well as wrinkles, sagging, spots and other skin caused by photoaging question. [0003] The function of trimethylglycine in betaine in skin care has also been used in the cosmetics industry for a long time. It can enhance the moisture, el...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/12C07C65/10C07C227/42C07C51/43A61K31/205A61K31/60A61P29/00A61P17/00A61P17/10A61P17/18A61P31/04A61K8/368A61K8/44A61Q17/00A61Q17/04A61Q19/00A61Q19/10
CPCC07C229/12C07C65/10A61P29/00A61P17/00A61P17/18A61P17/10A61P31/04A61K8/44A61K8/368A61Q17/005A61Q17/04A61Q19/10A61Q19/00C07B2200/13
Inventor 张嘉恒王振元韩知璇干瑞靖李雪云王天晓吴称玉
Owner SHENZHEN SHINESKY BIOLOGICAL TECH CO LTD
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