A film-coated drug-loaded microsphere, drug slow-release insect repellent pet collar and preparation method thereof
A drug-loaded microsphere and membrane-coated technology, applied in botany equipment and methods, animal repellants, chemicals for biological control, etc., to achieve good drug loading performance, good affinity and compatibility , Good effect of plasticizing processing
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Embodiment 1
[0062] Include by weight: 67.7 parts by weight of polyvinyl chloride, 22 parts by weight of film-coated drug-loaded microspheres, 3 parts by weight of dispersant, 0.3 parts by weight of antioxidant, 1 part by weight of stabilizer, 5 parts by weight of reinforcing agent, 1 part by weight of parts by weight additive;
[0063] The preparation steps of the deworming pet collar are as follows:
[0064] (1) Add 67.7 parts by weight of polyvinyl chloride to the mixing equipment, then add 3 parts by weight of dispersant, mix and disperse at room temperature for 15 minutes; then add 1 part by weight of stabilizer and 0.3 parts by weight of antioxidant, and mix and disperse for 10 minutes at room temperature; Add 22 parts by weight of film-coated drug-loaded microspheres, 5 parts by weight of enhancer and 1 part by weight of additives, set the temperature at 45°C, mix and disperse for 10 minutes, and obtain a uniform mixture for use;
[0065] (2) Add the homogeneous mixture obtained in...
Embodiment 2
[0070] Include by weight: 66.7 parts by weight of polyvinyl chloride, 22 parts by weight of film-coated drug-loaded microspheres, 3 parts by weight of dispersant, 0.3 parts by weight of antioxidant, 1 part by weight of stabilizer, 5 parts by weight of reinforcing agent, 2 parts by weight of parts by weight additive;
[0071] The preparation steps of the deworming pet collar are as follows:
[0072] (1) Add 66.7 parts by weight of polyvinyl chloride to the mixing equipment, then add 3 parts by weight of dispersant, mix and disperse at room temperature for 15 minutes; then add 1 part by weight of stabilizer and 0.3 parts by weight of antioxidant, and mix and disperse for 10 minutes at room temperature; Add 22 parts by weight of film-coated drug-loaded microspheres, 5 parts by weight of enhancer and 2 parts by weight of additives, set the temperature at 45°C, mix and disperse for 10 minutes, and obtain a uniform mixture for use;
[0073](2) Add the homogeneous mixture obtained i...
Embodiment 3
[0078] Include by weight: 65.7 parts by weight of polyvinyl chloride, 22 parts by weight of film-coated drug-loaded microspheres, 3 parts by weight of dispersant, 0.3 parts by weight of antioxidant, 1 part by weight of stabilizer, 5 parts by weight of reinforcing agent, 3 parts by weight of parts by weight additive;
[0079] The preparation steps of the deworming pet collar are as follows:
[0080] (1) Add 65.7 parts by weight of polyvinyl chloride to the mixing equipment, then add 3 parts by weight of dispersant, mix and disperse at room temperature for 15 minutes; then add 1 part by weight of stabilizer and 0.3 parts by weight of antioxidant, and mix and disperse for 10 minutes at room temperature; Add 22 parts by weight of film-coated drug-loaded microspheres, 5 parts by weight of enhancer and 3 parts by weight of additives, set the temperature at 45°C, mix and disperse for 10 minutes, and obtain a uniform mixture for use;
[0081] (2) Add the homogeneous mixture obtained ...
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