Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Application of telaprevir in preparation of medicine for treating ischemia/reperfusion injury and cell protection medicine

A technology for reperfusion injury and ischemic stroke, which is applied in the field of biomedicine to improve neurological function, reduce serum creatine kinase activity, and reduce the death of cardiomyocytes and nerve cells

Active Publication Date: 2021-10-26
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Telaprevir is a hepatitis C virus (HCV) NS3 / 4A serine protease inhibitor, which has antiviral effects by inhibiting HCV replication, but whether it has anti-ischemia / reperfusion injury effects has not been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of telaprevir in preparation of medicine for treating ischemia/reperfusion injury and cell protection medicine
  • Application of telaprevir in preparation of medicine for treating ischemia/reperfusion injury and cell protection medicine
  • Application of telaprevir in preparation of medicine for treating ischemia/reperfusion injury and cell protection medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Animal experiment: the protective effect of telaprevir on myocardial ischemia / reperfusion injury mouse model.

[0045] Experimental animals: 7-week-old male C57BL / 6J mice were fed for one week in an environment with a temperature of 25°C, a relative humidity of 60%, free access to water, and regular and quantitative amounts, and then administered according to the requirements of each group in the experiment.

[0046] Mouse myocardial ischemia / reperfusion model establishment method: 8-week-old male C57BL / 6J mice were anesthetized by intraperitoneal injection of 0.3% pentobarbital sodium (20mL / kg), orotracheal intubation, and pressure-sensitive adhesive Secure endotracheal tube. The ventilator parameters were set to a tidal volume of 3.2 mL / kg and a frequency of 110 breaths per minute. The left anterior descending artery (Left anterior descending, LAD) was ligated with an 8-0 banded suture after thoracotomy. Myocardial infarction could be judged by observing the whitenin...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to application of telaprevir in preparation of a medicine for treating ischemia / reperfusion injury and a cell protection medicine. The telaprevir is used for preparing the medicine for treating ischemia / reperfusion injury, particularly the medicine for treating myocardial cell and nerve cell injury, and the medicine particularly has a good protection effect (myocardial infarction and cerebral arterial thrombosis) on heart and cerebral ischemia / reperfusion injury, so that the heart and cerebral ischemia / reperfusion injury can be obviously relieved.

Description

technical field [0001] The invention relates to the application of telaprevir in the preparation of drugs for treating or preventing ischemia / reperfusion injury and cell protection drugs, and belongs to the field of biomedicine. The present invention provides new uses and administration methods of telaprevir, including protective effects on heart and cerebral ischemia / reperfusion (especially myocardial infarction and ischemic stroke), and reducing ischemia / reperfusion injury; And cytoprotective drugs are used to protect organs, tissues or cells against cell damage and dysfunction, which expands the scope of indications of telaprevir; in addition, the present invention also covers telaprevir in the preparation of myocardial cell injury and nerve Application of cell damage protection drugs. Background technique [0002] Myocardial infarction is mainly caused by cardiac ischemia. Without timely reperfusion or the absence of collateral circulation, cardiomyocytes are irreversi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/497A61P9/10A61P43/00A61P25/00A61P27/02
CPCA61K31/497A61P9/10A61P43/00A61P25/00A61P27/02
Inventor 罗秀菊彭军张议月李明睿
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com