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Method and system for treating type 2 diabetes mellitus by using astragalus flavone extract

A technology for type 2 diabetes mellitus and astragalus flavonoids is applied in the field of astragalus flavonoids extract for treating type 2 diabetes mellitus and systems, can solve problems such as high cost, and achieve the effects of simple method and system, good popularization and feasibility

Inactive Publication Date: 2021-10-22
WENZHOU MEDICAL UNIV
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Problems solved by technology

[0008] The present invention overcomes the high cost problem of β-cell gene knockout mice by constructing a type 2 diabetes mouse model, and simplifies the experiment for verifying the therapeutic effect of astragalus flavone extract on obesity-related diseases (such as type 2 diabetes)

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  • Method and system for treating type 2 diabetes mellitus by using astragalus flavone extract

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Experimental program
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Embodiment Construction

[0009] 1. Preparation of type 2 diabetes mouse model, group processing and histological examination

[0010] 40 12-week-old male C57BL / 6 mice (purchased from Shanghai Experimental Animal Center, Chinese Academy of Sciences), 40 SPF male C57BL / 6 mice (adaptive feeding for 1 week, randomly divided into 10 normal control NC groups) And the experimental group 30, the NC group was given conventional feed, the experimental group was given high sugar and high fat (MD12031 (gm% / kacl%) protein 19.2 / 20 fat 4.30 / 10 carbohydrate 67.3 / 70 trace elements 9.20 / 0) diet feeding. After 5 weeks, fast for 12 hours, intraperitoneally inject 1% streptozotocin 40mg / kg to induce diabetes model, fast for 4 hours after 72 hours, and take blood to measure FPG. Blood glucose concentration> 11.8mmol / L, and polydipsia, The symptoms of polyphagia and polyuria suggested that the diabetic mouse model was successfully induced. Administration of astragalus flavonoids was divided into model control (DM) group, mo...

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Abstract

The research is different from other previous researches, and the action mechanism of the astragalus flavone extract for treating the type 2 diabetes mellitus is discussed by applying a biological method. Skeletal muscle cells are taken as experimental subjects, an experimental group for blocking a P13 / Akt signal channel is constructed, then the astragalus flavone extract is given, liver cell related carbohydrate gene expression is analyzed, and the cellular mechanism of the astragalus flavone extract for treating type 2 diabetes mellitus is discussed. At present, the research is not reported at home and abroad. Therefore, a novel treatment method is provided by the astragalus flavone extract. By using the method, lots of expenditures for purchasing db / db mice and double-gene knockout mice can be saved. According to the research, the protein expression level of an insulin receptor substrate P-IRS-1 is measured, then the influence of the astragalus flavone extract on the insulin sensitivity of mouse myoblasts (C2C12) is detected, and a theoretical basis is provided for treatment of type 2 diabetes mellitus.

Description

technical field [0001] The field of treating obesity-related diseases (such as type 2 diabetes) by extracts of astragalus flavones, in particular involves verifying the feasibility of extracts of astragalus flavones for treating type 2 diabetes. Background technique [0002] Studies have shown that diabetes has become an endocrine and metabolic disease that seriously threatens human health. Type II diabetes accounts for more than 95% of diabetic patients. The risk of malignant tumors such as colorectal cancer, liver cancer, and breast cancer in patients with type II diabetes is significantly higher than that of the general population. Insulin resistance is a common cause of diseases such as type II diabetes and cardiovascular disease in obese and susceptible individuals. [0003] Since type 2 diabetes patients need to take medicines for a long time to control blood sugar, so this puts forward higher requirements for the safety of anti-type 2 diabetes drugs. Although a var...

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Application Information

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IPC IPC(8): A61K36/481A61K49/00A61P3/10
CPCA61K36/481A61K49/0008A61P3/10
Inventor 肖敏
Owner WENZHOU MEDICAL UNIV
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