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Depression assessment method and system based on candidate gene methylation sequencing and deep learning

A candidate gene, deep learning technology, applied in the field of data identification, to avoid subjective factors

Active Publication Date: 2021-10-19
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is easily affected by subjective factors such as the degree of cooperation of the patient and the proficiency of the doctor.

Method used

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  • Depression assessment method and system based on candidate gene methylation sequencing and deep learning
  • Depression assessment method and system based on candidate gene methylation sequencing and deep learning
  • Depression assessment method and system based on candidate gene methylation sequencing and deep learning

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Embodiment Construction

[0042] Below in conjunction with accompanying drawing, the present invention is described in further detail:

[0043] The present invention provides a depression assessment method based on candidate gene methylation sequencing and deep learning, such as figure 1 As shown, it specifically includes the following steps:

[0044] Step 1: Collect and organize the data, and construct the original data set, where the data set data includes the beta value of the DNA methylation sequencing results of the candidate gene DNA methylation of the depression patients and healthy controls, demographic data, diagnostic scale data and candidate genes SNP data.

[0045] 300 depressive patients and 100 healthy controls who met the criteria were obtained, and DNA methylation sequencing of candidate genes, clinical data collection and scale data statistics were performed on them. A large-scale study of depressed patients and healthy controls using the Life Events Scale (LES) and the Child Trauma ...

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Abstract

The invention discloses a depression assessment method and system based on candidate gene methylation sequencing and deep learning, and the method comprises the steps: constructing an original data set, and carrying out data preprocessing to obtain an experimental data set; performing feature selection on the experimental data set, screening out difference features of the depression patient and the healthy control, and constructing an input data set; dividing the input data set into a training data set and a test data set according to a certain proportion; creating a deep learning model for identifying depression patients and healthy people, and training the constructed deep learning model by using the training data set; performing performance evaluation on the trained deep learning model by using the test set, and continuously optimizing the model in a verification evaluation process to obtain an optimal model. According to the method, the potential depression patients can be rapidly and preliminarily evaluated, subjective factors are prevented from being introduced during interview evaluation of clinicians and self-evaluation of the patients, the influence on results is avoided, and the accuracy of depression diagnosis is improved.

Description

technical field [0001] The invention belongs to the field of data identification, in particular to a method and system for evaluating depression based on candidate gene methylation sequencing and deep learning. Background technique [0002] Clinical identification and diagnosis of depression is mainly based on patient interviews, scales, and doctor's experience in diagnosis and treatment. This method is easily affected by subjective factors such as the degree of cooperation of the patient and the proficiency of the doctor. Therefore, it is of great significance to find a fast, objective and accurate assessment method for depression for individual treatment. Contents of the invention [0003] Purpose of the invention: The present invention provides a depression assessment method and system based on candidate gene methylation sequencing and deep learning, which can quickly and accurately assess patients with potential depression and assist doctors in judging whether they ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/20G16B20/30G16B40/00G06N3/04A61B5/16
CPCG16H50/20G16B20/30G16B40/00A61B5/165G06N3/045
Inventor 李健徐治胡云云袁勇贵
Owner SOUTHEAST UNIV
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