Application of phytol in preparation of anti-migraine medicine

A technology of migraine and phytol, which is applied in the direction of drug combination, active ingredients of hydroxyl compounds, nervous system diseases, etc., can solve the problems of poor treatment effect of migraine, achieve good anti-migraine activity, good therapeutic effect, and reduce head scratching The effect of the number of times

Pending Publication Date: 2021-10-12
YUNNAN MINZU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved in the present invention is to solve the problem that the compounds in the prior art have poor therapeutic effect on migraine

Method used

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  • Application of phytol in preparation of anti-migraine medicine
  • Application of phytol in preparation of anti-migraine medicine
  • Application of phytol in preparation of anti-migraine medicine

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0042] The invention also provides a method for preparing the diterpene compound phytol, which includes preparing the compound from silkworm excrement. Preferably, phytol is prepared from silkworm excrement. Preferably, the method has the steps of:

[0043] (1) extracting with solvent after pulverizing silkworm excrement, and merging the extract;

[0044] (2) concentrating under reduced pressure the extract in (1) to obtain extractum;

[0045] (3) suspending the extract in (2) in water, extracting with sherwood oil, ethyl acetate and n-butanol successively, and then steaming off the solvent with a rotary evaporator to obtain sherwood oil, ethyl acetate and n-butanol respectively. butanol extract;

[0046] (4) The petroleum ether extract in (3) was separated by silica gel column chromatography, and 10 components (Fr.1 ~10).

[0047] (5) The Fr.2 in (4) was chromatographed on a silica gel column and eluted with a gradient of petroleum ether-ethyl acetate (volume ratio 100:1...

Embodiment 1

[0058] Example 1: Anti-migraine activity test of silkworm excrement extract

[0059] Source of material: The silkworm excrement belonging to the genus Silkworm excrement was collected in Kunming, Yunnan Province, and was identified as Faeces bombycis by Associate Professor Yang Qingsong, College of Ethnic Medicine, Yunnan University for Nationalities. The specimens are preserved in the Herbarium of the School of Medicine for Nationalities, Yunnan University for Nationalities.

[0060] Preparation of silkworm excrement extract: crush the dried silkworm excrement to obtain silkworm excrement fragments; then extract the silkworm excrement fragments with 95% ethanol / water reflux for 3 times, each time for 2 hours to obtain an extract; The extracts were filtered and concentrated under reduced pressure with a rotary evaporator to obtain an extract for later use.

[0061] A rat model of migraine induced by nitroglycerin (see scientific literature: Zhang Xiao-Fan, Zhang Wen-Jun, Dong...

Embodiment 2

[0066] Embodiment 2: further test with silkworm excrement

[0067] Example 1 was repeated using 95% methanol / water, 70% ethanol / water and 80% acetone / water as extraction solvents respectively. The experimental results showed that 95% methanol extract of silkworm excrement, 70% ethanol extract of silkworm excrement and 80% acetone were obtained by using 95% methanol / water, 70% ethanol / water and 80% acetone / water as extraction solvents respectively. The extract of / water also has significant anti-migraine effect on rats, so the anti-migraine active ingredients in silkworm excrement can also be obtained by using different concentrations of ethanol / water, methanol / water or acetone / water as extraction solvents. The results are shown in Table 2.

[0068] Table 2 The effect of different solvent extracts of silkworm excrement on the number of head scratching in migraine rats

[0069]

[0070] n=10

[0071] Note: # Compared with the blank control group, P## Compared with the blank...

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Abstract

The invention relates to application of a diterpenoid phytol in preparation of an anti-migraine medicine. The phytol can be a natural organic compound or a synthetic organic compound, has relatively high anti-migraine activity, and is used as an active component to be prepared into the anti-migraine medicine or a medicine composition together with a pharmaceutically acceptable carrier or an auxiliary material.

Description

technical field [0001] The present invention relates to the use of a diterpene compound in the preparation of anti-migraine medicine, in particular to the use of phytol in the preparation of anti-migraine medicine. Background technique [0002] Migraine is the most common type of headache clinically. Generally, there is no organic lesion. The main clinical manifestation is paroxysmal moderate to severe, throbbing headache, with pain on one or both sides of the head. Migraine is often related to genetics, and people with poor physical fitness, who do not like sports and engage in mental work are more likely to suffer from migraine. Migraine mainly includes three categories: typical migraine, common migraine and cluster migraine. Typical migraine patients are mostly periodic attacks, and women are more common. Before the onset, most patients may experience blurred vision, flashes of light, hallucinations, blind spots, eye swelling, and emotional instability. Almost all patie...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P25/06
CPCA61K31/045A61P25/06
Inventor 黄相中李艳红白溪山李育晓李红锐
Owner YUNNAN MINZU UNIV
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