Detection system and method for noninvasive measurement of tissue deoxidation, oxygenation and carbonyl hemoglobin

Abstract

The invention discloses a detection system and method for noninvasive measurement of tissue deoxyhemoglobin, oxyhemoglobin and carbonyl hemoglobin. The detection system comprises a probe and a host; the probe is composed of an upper cover layer, a shell, a signal receiving module and a lower cover layer; and the signal receiving module is composed of an optical filter and a detector, and the shell, the optical filter and the detector are located between the upper cover layer and the lower cover layer to form a sandwich structure. The host is composed of a power supply module, a light source driving module, a light source, a central processing module, a display module, a storage module, a signal processing module and a user information input module. The host and the probe are connected through a cable capable of transmitting optical signals and a cable capable of transmitting electric signals, the probe is completely attached to human tissue, the light source driving module in the host controls a light source to emit light, the signal processing module processes photoelectric signals of the signal receiving module and transmits the photoelectric signals to the storage module, the central processing module calls data in the storage module, the central processing module calculates the data and then the data is displayed through the display module. According to the invention, tissue deoxyhemoglobin, oxyhemoglobin and carbonyl hemoglobin can be noninvasively measured at the same time.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to a detection system and method for noninvasively measuring tissue deoxygenation, oxygenation and carboxyhemoglobin. Background technique [0002] Hemoglobin is a special protein in red blood cells, accounting for 97% of the total red blood cells. Its main physiological function is to transport oxygen from the lungs to the various tissue cells of the body, and then transport the carbon dioxide breathed by each tissue cell to the lungs. Exhale. [0003] Oxyhemoglobin (oxyhemoglobin, HbO 2 ), deoxyhemoglobin (deoxyhemoglobin, Hb) and carboxyhemoglobin (carboxyhemoglobin, HbCO) content are three important physiological indicators. Oxyhemoglobin is a substance produced by the reversible combination of hemoglobin and oxygen molecules, which has the function of transporting oxygen. Deoxyhemoglobin is hemoglobin without oxygen. Carboxyhemoglobin is the product of hemoglob...

AI Technical Summary

Problems solved by technology

However, the patents, papers and products disclosed above can only be used for the measurement of fingertip pulse carboxyhemoglobin saturation, and cannot be used for the measurement of carboxyhemoglobin content in tissues

Since fingertip pulse carboxyhemoglobin detection can only reflect the systemic arterial carboxyhemoglobin status, but cannot reflect the carboxyhemoglobin status of a certain local tissue (such as brain tissue, muscle tissue, etc.), even if the fingertip pulse carboxyhemoglobin value is normal, there is no The possibility of local tissue hypoxia cannot be ruled out

[0008] In summary, there is no system and method for simultaneously non-invasively detecting the content of deoxyhemoglobin, oxyhemoglobin and carboxyhemoglobin in the published materials, and there is an urgent need for a system and method that can simultaneously non-invasively detect the content of deoxyhemoglobin, oxyhemoglobin and carboxyhemoglobin in tissues The system and method are used for clinical comprehensive evaluation of blood oxygen metabolism in tissues, and provide objective basis for timely handling of adverse events

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