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Altrenogest injection as well as preparation method and application thereof

A technique of tetraethylestrone and injection, which is applied in the field of aquaculture, can solve the problems of increased viscosity, coagulation, and decreased convenience of use of medicinal liquid, and achieves the effects of reducing labor costs, improving production efficiency, and being convenient and quick to use.

Active Publication Date: 2021-09-17
NINGBO SANSHENG BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The solvent of oral tetraenestrone is generally soybean oil or other oily solvents, which are easy to solidify at low temperature, especially in winter, the viscosity of the liquid will be greatly increased or even solidified, which will greatly increase the convenience of use decline

Method used

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  • Altrenogest injection as well as preparation method and application thereof
  • Altrenogest injection as well as preparation method and application thereof
  • Altrenogest injection as well as preparation method and application thereof

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preparation example Construction

[0045] The embodiment of the present invention provides a preparation method of tetraenestrone injection, which includes: mixing the components of the tetraenestrone injection according to the proportion.

[0046] "According to the proportion" herein refers to the proportion of the components of the tetratenestrone injection described in any of the foregoing embodiments.

[0047] Preferably, when the alcoholic solvent includes ethanol, glycerol, isopropanol and 1,2-propanediol, the preparation method comprises: first mixing ethanol, glycerol, isopropanol and polyethylene glycol in proportion Mix, then add tetraenyl estradiol in proportion, after mixing, add 1,2-propanediol and mix to obtain a uniformly mixed semi-finished solution; filter the semi-finished solution through an organic microporous membrane, potting, capping and rolling After capping, the finished tetraenestrone injection is obtained.

[0048] An embodiment of the present invention also provides a method for rai...

Embodiment 1～17

[0055] Embodiments 1 to 17 provide a tetraenestrone injection and a preparation method thereof. The components of the tetraenestrone injection are roughly the same, the difference is that the components or their proportions used in each embodiment are different, and the details can be Refer to Table 1.

[0056] Table 1 Tetraenestrone Injection Formula

[0057]

Embodiment 1

[0059] The preparation method of embodiment 1 is as follows:

[0060] Get each component according to the proportioning ratio shown in table 1, at first polyethylene glycol and alcoholic solvent (being glycerol, isopropanol and ethanol in embodiment 1) are added in proportion to the batching tank, after mixing evenly, press Proportional addition of tetraenylestradiol; dark operation, stirring at a stirring speed of 200rpm for 25min, after the material was completely dissolved, adding the remaining amount of alcohol solvent (1,2-propylene glycol in Embodiment 1) to 100mL, and continuing to stir at a stirring speed of 200rpm Stir at a high speed for 25 minutes to obtain a uniformly mixed semi-finished solution, which is set aside; then filter through 0.45 μm and 0.22 μm organic microporous membranes in sequence, potting, capping, and capping to obtain the finished tetraenestrone injection.

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Abstract

The invention discloses an altrenogest injection as well as a preparation method and application thereof, and relates to the technical field of breeding. Each 100 mL of the altrenogest injection comprises the following components: 0.1 to 35 g of altrenogest, 0.01 to 70 mL of polyethylene glycol and the balance of an alcohols solvent. The provided altrenogest injection can effectively inhibit oestrus of sows, synchronize the oestrus cycle of the sows, increase the total litter size and live litter size, and greatly improve the production efficiency of large-scale pig farms; the injection is convenient and fast to use, the dosage is more accurate and controllable, the technical problem of follicular cyst caused by insufficient intake dosage of the sows is avoided, the oestrus of the sows can be effectively inhibited for 6-12 days by single injection, daily administration is not needed, and the labor cost of a large-scale farm is remarkably reduced.

Description

technical field [0001] The invention relates to the technical field of breeding, in particular to a tetraenylestrone injection and its preparation method and application. Background technique [0002] Altrenogest, CAS No.: 850-52-2, is a synthetic steroidal progestin, its chemical name is 17α-allyl-17-hydroxyestr-4,9,11 - Trien-3-ones. The mechanism of action is similar to that of natural progesterone. It mainly adjusts the estrous cycle of female animals by inhibiting gonadotropins (Sitrukware, R., 2004). It also has weak estrogen, androgen and anabolic effects, without adrenal hormones and anti-inflammation The role of (Feng Yanyan et al., 2020). [0003] Oral preparations of tetraenestrone were first approved for marketing in France in 1984, developed by INTERVET INTERNATIONAL B.V. (an animal health company under Merck, also known as MSD Animal Health, referred to as "MSD"), in 1990 Approved by the FDA to enter the US market. It is mainly used to regulate the estrous ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/567A61K47/10A61P15/08A61P5/30
CPCA61K31/567A61K9/08A61K9/0019A61K47/10A61P15/08A61P5/30
Inventor 郑兴昌周思超吴欢听李玉巧刘彦平于国伟李晓虹姚珍珍舒佳妮邵梦瑜戚岑聪翁士乔周立明
Owner NINGBO SANSHENG BIOLOGICAL TECH CO LTD
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