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A kind of hypoirritant plant enzyme whitening nano composition and its preparation method and application

A nano-composite, plant enzyme technology, applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations and other directions, can solve the problems of low bioavailability of active ingredients, poor transdermal absorption of active ingredients, and poor product stability, etc. The effect of reducing the risk of skin sensitization and acne, improving bioavailability and good transdermal absorption

Active Publication Date: 2022-03-25
RAYTING BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the following problems generally exist in the whitening skin care products on the market: it is difficult to achieve the significant effect expected by consumers when used at low concentrations; more serious contact dermatitis, allergies and other problems will occur when the usage is increased, which is manifested as redness and swelling of the skin , itching, pain and other manifestations; the product has poor stability and is sensitive to light, heat, and metal ions; the bioavailability of active ingredients is low; the transdermal absorption of active ingredients is poor

Method used

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  • A kind of hypoirritant plant enzyme whitening nano composition and its preparation method and application
  • A kind of hypoirritant plant enzyme whitening nano composition and its preparation method and application
  • A kind of hypoirritant plant enzyme whitening nano composition and its preparation method and application

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preparation example Construction

[0034] The preparation method of plant ferment among the present invention is as follows:

[0035] Take plant leaves, crush them through a 60-100 mesh sieve, add 50-75g / L to deionized water, and add 10g / L of glucose at the same time to adjust the pH of the system to 4.5-5.0;

[0036] Sterilize the fermentation medium at 121°C and 0.1Mpa for 20 minutes to prepare the sterilized fermentation medium;

[0037] Inoculate Lactobacillus plantarum in MRS medium, culture at 37°C, 200rpm for 18-24h, until the bacterial concentration reaches 10 6 ~10 7 In the case of CFU / mL, inoculate 5% to 10% of the inoculum in the sterilized fermentation medium for fermentation and culture, and filter with a ceramic membrane to obtain the Centella asiatica fermentation filtrate; wherein,

[0038] Plantarum inoculated with Lactobacillus plantarum was cultured at 35±2°C and 200rpm for 48-72h, and when the residual sugar reached 0, the fermentation was terminated; after fermentation, the fermentation l...

Embodiment 1

[0041] Prepare the sample according to the raw material ratio in Table 1, mix the active substance, oil, light stabilizer, and antioxidant to obtain the oil phase, and heat it in a water bath with magnetic stirring until it is completely dissolved;

[0042] Mix the emulsifier, co-solvent, plant enzyme and chelating agent to obtain the water phase, heat and stir in a water bath until completely dissolved;

[0043] Add the oil phase to the water phase, disperse at 15,000 rpm at high speed for 3 minutes, and then use high-pressure homogenization technology, 80MPa, and cycle 6 times to prepare the obtained sample.

[0044] Table 1 sample raw material ratio table (%)

[0045]

[0046]

[0047]

Embodiment 2

[0049] The particle size results of each sample are shown in Table 2, as follows:

[0050] Table 2

[0051]

[0052] It can be seen from Table 2 that the nanoemulsion composed of plant enzyme-whitening active substance-other additives has the best thermal stability.

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Abstract

The invention discloses a low-irritation plant enzyme whitening nano composition, a preparation method and application thereof, including fat-soluble whitening active substances, plant enzymes, oil, cosolvent, emulsifier and other additives. Wherein the whitening active substance is 0.1-10%, the oil is 1-10%, the co-solvent is 20-60%, the emulsifier is 0.5-10%, and the other additives are 0.1-1% , the balance is supplemented to 100% by plant enzymes; the whitening active substance is one or more of phenylethyl resorcinol, 4-butyl resorcinol, and hexyl resorcinol. The present invention uses plant enzymes and whitening actives in combination, can increase the effective use concentration of whitening actives, and at the same time reduce its irritation, greatly expanding its applicability.

Description

technical field [0001] The invention belongs to the technical field of micro-nano carriers, and in particular relates to a low-irritation plant enzyme whitening nano composition, a preparation method and an application thereof. Background technique [0002] With the improvement of living standards, people pay more and more attention to skin care (especially the care and maintenance of facial skin). [0003] In recent years, people have higher and higher requirements for cosmetics necessary for life, not only requiring better efficacy, but also paying great attention to the safety problems of the skin caused by them. [0004] At present, the following problems generally exist in the whitening skin care products on the market: it is difficult to achieve the significant effect expected by consumers when used at low concentrations; more serious contact dermatitis, allergies and other problems will occur when the usage is increased, which is manifested as redness and swelling of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/34A61Q19/02
CPCA61K8/9789A61K8/347A61Q19/02A61K2800/85
Inventor 杜养标骆晔媛赵炳天梁蓉
Owner RAYTING BIOTECHNOLOGY CO LTD
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