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Experimental device and method for guiding mouse to search for escape platform through visual clues

An escape platform, a technology of visual cues, applied in the field of behavioral research

Active Publication Date: 2021-09-14
WENZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Moreover, the electroretinogram and visual evoked potentials have the limitation that they can only reflect the function of the retina or the visual nerve pathway.

Method used

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  • Experimental device and method for guiding mouse to search for escape platform through visual clues
  • Experimental device and method for guiding mouse to search for escape platform through visual clues
  • Experimental device and method for guiding mouse to search for escape platform through visual clues

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Experimental program
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Embodiment Construction

[0035] Embodiments of the present invention will be further described below in conjunction with accompanying drawings:

[0036] Such as Figure 1-2 As shown, an experimental device for guiding mice to find an escape platform by visual cues, including base 1, center platform 2, escape platform 3, and LED4.

[0037] A circular water tank 11 is formed on the base 1. The diameter of the circular water tank 11 is 200 cm and the depth is 30 cm. The inner wall of the circular water tank 11 is sprayed with white paint.

[0038] The central platform 2 and the escape platform 3 adopt a cylindrical platform of the same specification, made of plexiglass, with a diameter of 5 cm and a height of 14.5 cm, and 6-9 grooves with a diameter of 0.5 cm are provided on the upper surface. So that the experimental mice can stand still.

[0039] The LED4 is a common red or white LED in the market. The red LED can emit red flashing light with a wavelength of 615-650nm. The power of the lamp is 0.5W, ...

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Abstract

The invention discloses an experimental device and method for guiding a mouse to find an escape platform through visual clues. The experimental device is characterized by comprising a base with a circular water tank, a center platform, the escape platform and an LED; LED flickering is used as a visual clue, so that the experimental mouse is guided to swim to the escape platform and escape is realized; and the visual function of the experimental mouse can be quantitatively analyzed according to recorded escape time. The experimental device and method have the advantages that compared with conventional electroretinogram or visual evoked potential detection, anesthesia is not needed, noninvasive detection can be achieved, visual behaviors serve as the research basis, the detected visual function range can cover sn area from retina to cerebral visual cortex center and other cerebral cortex areas related to the visual center, and is the experimental device and method are associated with a motion system.

Description

technical field [0001] The invention relates to the technical field of behavioral research, in particular to an experimental device and method for guiding mice to find an escape platform by visual clues. Background technique [0002] Among human hereditary retinal diseases, some are scotopic dysfunction, mainly manifested as night blindness; some are photopic dysfunction, mainly manifested as day blindness; some are both dysfunctional, manifested as total blindness. Before trying gene, stem cell or any other new method of treatment on these patients, rigorous animal experiments must be carried out to verify the effectiveness of the treatment. In these preclinical basic research, mice are widely used experimental animals. Since it is impossible to communicate effectively with animals, observing the behavioral performance related to vision can enable researchers to indirectly understand the changes in the visual function of animals after treatment. In the mouse model of visu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B3/02
CPCA61B3/02A61B2503/40A61B2503/42Y02B20/40
Inventor 戴旭锋保金华陈浩
Owner WENZHOU MEDICAL UNIV
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