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Molecular marker for detecting/evaluating curative effect of premature schizophrenia and application of molecular marker

A technology for molecular markers and schizophrenia, applied in the field of molecular markers for detection/evaluation of early-onset schizophrenia, can solve problems such as misdiagnosis and missed diagnosis, lack of objective physiological, biochemical and pathological indicators, and achieve excellent specificity performance and improve the detection accuracy

Pending Publication Date: 2021-09-07
FIRST HOSPITAL OF SHANXI MEDICAL UNIV +3
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this diagnostic method still mainly relies on clinical interviews with psychiatrists, lacking objective physiological, biochemical and pathological indicators; the evaluation of curative effect is also mainly based on changes in symptomology, and this relatively subjective judgment can easily lead to misdiagnosis and missed diagnosis

Method used

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  • Molecular marker for detecting/evaluating curative effect of premature schizophrenia and application of molecular marker
  • Molecular marker for detecting/evaluating curative effect of premature schizophrenia and application of molecular marker
  • Molecular marker for detecting/evaluating curative effect of premature schizophrenia and application of molecular marker

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Experimental program
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Effect test

Embodiment

[0056] This embodiment is a screening method for molecular markers for detection / efficacy evaluation of early-onset schizophrenia. The screening method includes the following steps:

[0057] (1) Collect peripheral plasma samples from 10 cases of early-onset schizophrenia and 10 matched healthy controls;

[0058] (2) Extract the RNA in the peripheral plasma samples separately, and use the total RNA of each sample to prepare a sequencing library, specifically including:

[0059] a. Pretreat 5 μg of total RNA and use CircRNA Enrichment Kit (Cloud-seq, USA) to enrich circRNA;

[0060] b. Use TruSeq Stranded Total RNA Library Prep Kit (Illumina, San Diego, CA, USA) to perform reverse transcription of circRNA and construct a sequencing library;

[0061] c. Use BioAnalyzer 2100 instrument (Agilent Technologies, USA) for library quality control and quantification;

[0062] (3) According to the Illumina sequencing instructions, denature the library into single-stranded DNA molecules,...

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Abstract

The invention discloses a molecular marker for detecting / evaluating curative effect of premature schizophrenia and application of the molecular marker. The molecular marker is hsa_circ_0000397, and the nucleotide sequence of the molecular marker is as shown in SEQ ID NO: 1. The molecular marker has a correlation relationship with the schizophrenia, can quickly, simply and accurately realize auxiliary diagnosis of the schizophrenia, and provides a basis for schizophrenia diagnosis and curative effect evaluation index selection.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a molecular marker for detecting / evaluating early-onset schizophrenia and its application. Background technique [0002] Schizophrenia is one of the most common clinical severe mental disorders, which seriously endangers the physical and mental health of human beings and brings heavy burdens to families and society. Early-onset schizophrenia (EOS) specifically refers to schizophrenia with onset before the age of 18. Compared with adult patients with schizophrenia, patients with early-onset schizophrenia show more significant prodromal neurodevelopmental abnormalities, more serious family genetic burden, and poorer long-term prognosis. [0003] So far, the diagnostic system that relies solely on symptomology is still the gold standard for the diagnosis of schizophrenia, such as the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (DSM-5) and the International Cla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12Q1/686C12N15/113
CPCC12Q1/6883C12Q1/686C12Q2600/178C12Q2600/106C12Q2600/166C12Q2561/113C12Q2563/107C12Q2545/114
Inventor 刘莎徐勇李泽萱李忻蓉杜鑫哲
Owner FIRST HOSPITAL OF SHANXI MEDICAL UNIV
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