Application of ensrnot00000084277 in the preparation of drugs for the prevention and treatment of chronic pain-related depression
A technology for chronic pain and drugs, which is applied in the field of preparation of drugs for the prevention and treatment of depression related to chronic pain. It can solve the problems of affecting the quality of life of patients, having no treatment means, and aggravating the pain feeling, so as to achieve the effect of improving depression-like behaviors.
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[0026] 1. Main experimental methods:
[0027] (1) Experimental animals: Healthy male SPF SD rats were provided by the Experimental Animal Center of Xuzhou Medical University, weighing 200-220 g.
[0028] (2) Preparation of neuropathic pain model: SD rats were randomly divided into sham operation group (Sham) and SNI model group. In the SNI model group, the neuropathic pain model was established by selective sciatic nerve branch injury. The skin was incised along the outer depression of the femur on the left thigh of the rat, and a long incision of about 1-2 cm was made. The surrounding tissue was bluntly separated to expose the three branches of the rat sciatic nerve, and the sural nerve was preserved. tibial and common peroneal nerves. The incision was sutured with 4.0 silk suture. Rats in the Sham group only exposed the sciatic nerve without ligation. All experiments were performed in strict compliance with aseptic principles.
[0029](3) Determination of mechanically s...
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