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Vetilpofungin-loaded microneedle for scar repair and preparation method and application thereof

A verteporfin and microneedle technology, applied in the field of verteporfin-loaded microneedles and its preparation, can solve the problems of poor drug permeability, high frequency of administration, difficulty in maintaining drug concentration, etc., and achieve strong permeability, The effect of low cost and simple operation

Pending Publication Date: 2021-08-13
NANJING DRUM TOWER HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when verteporfin is used directly, the drug has poor permeability, the drug concentration is difficult to maintain, and the high frequency of administration will increase the clinical burden

Method used

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  • Vetilpofungin-loaded microneedle for scar repair and preparation method and application thereof
  • Vetilpofungin-loaded microneedle for scar repair and preparation method and application thereof
  • Vetilpofungin-loaded microneedle for scar repair and preparation method and application thereof

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Embodiment 1

[0024] This embodiment is a microneedle loaded with verteporfin, and the preparation method is as follows:

[0025] S1. Fabricate microneedle templates by laser etching silica gel substrates;

[0026] S2. Take 500 µL of methacrylate gelatin solution (30% v / v, solvent is deionized water) as the hydrogel precursor solution, add photoinitiator 2-hydroxy-2-methylphenyl to the solution Acetone (1% v / v), add 0.01 mg verteporfin and mix thoroughly, then add to the microneedle template, and vacuum for 5 minutes to make the solution completely fill the microneedle tip. Irradiate under UV light for 10 seconds to completely cure the hydrogel, and gently peel off the microneedles from the template to finally get the figure 1 The microneedle loaded with verteporfin shown in .b, the size of the microneedle base plate is 1cm×1cm, the thickness of the microneedle base is 300 μm, the microneedle array is 10×10, each microneedle is in the shape of a pyramid, and the microneedle The radius is ...

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Abstract

The invention discloses a vilepofen-loaded microneedle for scar repair and a preparation method and application thereof. The vilepofen-loaded microneedle is prepared by mixing vilepofen into a hydrogel precursor solution, filling the gap of a microneedle template with the mixture, and removing the template after the solution is solidified. The loaded vilepofen can be slowly released from the microneedle; the needle tip of the microneedle is high in penetrability, and the permeability of vilepofen in a scar can be enhanced; the morphology of the needle tip can be adjusted according to the application environment of scar treatment; and the loading amount of vilepofen can be adjusted according to the severity of the scar.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a verteporfin-loaded microneedle for scar repair, a preparation method and application thereof. Background technique [0002] Human skin often develops fibrotic scar tissue as part of the wound healing process. Unlike normal skin, scars do not have dermal appendages such as hair follicles, glands, etc. In normal skin, there is a "basket net" fibrous extracellular matrix, which gives the skin elasticity and strength, while in scars, dense, parallel fibers are formed. This change in fiber structure makes scar tissue weaker than uninjured skin. Scarring causes disfigurement, growth restriction, and permanent loss of function, and costs the world enormously every year. Ideally, a treatment to prevent scarring should restore the skin appendages and normal matrix structure to a strength comparable to that of normal skin. Despite decades of research, wound healing with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/409A61K47/42A61M37/00A61P17/02
CPCA61K31/409A61K9/0021A61K47/42A61P17/02A61M37/0015A61M2037/0053
Inventor 赵远锦陈国璞王逢源王月桐张大淦商珞然
Owner NANJING DRUM TOWER HOSPITAL
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