Colloidal gold test paper for detecting A-beta antigen in senile dementia serum and use method of colloidal gold test paper

A colloidal gold test paper, Alzheimer's disease technology, applied in the direction of biological testing, measuring devices, disease diagnosis, etc., can solve problems such as physical centrifugation difficulties

Inactive Publication Date: 2021-07-30
瑞吉瑞得医药生物科技(无锡)有限公司
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Problems solved by technology

However, physical centrifugation is difficul

Method used

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Embodiment Construction

[0015] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of them.

[0016] This embodiment provides a colloidal gold test paper for the detection of A-beta antigen in the serum of Alzheimer's disease. Specifically, the colloidal gold test paper includes a marker pad, and two detection lines are respectively arranged on the marker pad for detecting A-beta antigen. -beta antigen, one of the detection lines is coated with an antibody that can recognize A-beta40, and the other detection line is coated with an antibody that can recognize A-beta42.

[0017] Colloidal gold test paper can be applied to patients with dementia who need to monitor the course of Alzheimer's disease at any time, or are in the period of changing drugs.

[0018] Also prepare a buffer, which includes Tris hydrochloride, sodium heparin, BS...

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Abstract

The invention discloses colloidal gold test paper for detecting an A-beta antigen in senile dementia serum and a use method of the colloidal gold test paper, and relates to the technical field of whole blood sample pretreatment, the colloidal gold test paper comprises a labeling pad, and is characterized in that two detection lines are arranged on the labeling pad respectively and used for detecting the A-beta antigen, one detection line is coated with an antibody capable of recognizing A-beta40, and the other detection line is coated with an antibody capable of recognizing A-beta42. According to the colloidal gold test paper, a whole blood sample is pretreated by using a brand new designed Tris buffer solution, so that A-beta40 and 42 of the blood sample to be detected can be detected on the colloidal gold test paper, and the colloidal gold test paper is suitable for senile dementia patients who need to monitor the course of Alzheimer's disease at any time or are in the period of medicine replacement.

Description

technical field [0001] The invention relates to the technical field of whole blood sample pretreatment, in particular to a colloidal gold test paper for detecting A-beta antigen in serum of senile dementia and its application method. Background technique [0002] Alzheimer's disease (senile dementia) is a serious and fatal central nervous system disease that affects the health of middle-aged and elderly people. In the blood of Alzheimer's patients, the content of two short peptides A-beta40 and A-beta42 will increase, and the change of the ratio of the two indicates the change of the disease course. When the content of A-beta42 increases, it indicates that Alzheimer's disease is gradually deepening, and when the concentration of A-beta42 decreases and / or A-beta40 increases, it indicates that the course of Alzheimer's disease is slowed down. The detection of A-beta40 and 42 in the blood of Alzheimer's patients generally requires the use of anticoagulant blood, the separation...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/58G01N33/543
CPCG01N33/6896G01N33/587G01N33/54346G01N2800/2821
Inventor 石崧
Owner 瑞吉瑞得医药生物科技(无锡)有限公司
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