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Photosensitive bioabsorbable polymer with in-situ cell adhesion resistance function and preparation method ofphotosensitive bioabsorbable polymer

A technology of absorbing polymers and photosensitivity, which is applied in the field of biomedical polymer material technology and photocuring, which can solve the problems of easy peeling off of the coating and failure of coating modification, and achieve fast curing speed, low cost, and good bioabsorption sexual effect

Pending Publication Date: 2021-07-27
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since both PLA and the coating carrier are bioabsorbable materials, as the implantation time increases, they will gradually degrade in the human body, and the coating is easy to peel off, which leads to the failure of coating modification.

Method used

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  • Photosensitive bioabsorbable polymer with in-situ cell adhesion resistance function and preparation method ofphotosensitive bioabsorbable polymer
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  • Photosensitive bioabsorbable polymer with in-situ cell adhesion resistance function and preparation method ofphotosensitive bioabsorbable polymer

Examples

Experimental program
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Effect test

Embodiment 1

[0033] This embodiment 1 provides a photosensitive bioabsorbable polymer with in situ anti-cell adhesion function, and the specific formula (100 grams) is as follows:

[0034] FAME-modified three-arm photosensitive lactic acid oligomer (FAME-3arms-LAO) 45g

[0035] NVP 55g

[0036] Irgacure 2959 5g

[0037]Wherein, the three-arm type photosensitive lactic acid oligomer (three-arm lactic acid oligomer with double bond) modified by FAME (monoethyl fumarate) is prepared by the following method:

[0038] (1) Add 100g of ethyl acetate and 80g of L-lactide in turn to a round-bottomed flask, and continue to reflux and stir at 75°C until the L-lactide is completely dissolved; then the resulting solution is filtered under reduced pressure and the filtrate is collected; the filtrate Ice bath for more than 5 hours until the needle-like L-lactide crystals are completely precipitated; filter under reduced pressure again, and vacuum-dry to obtain purified L-lactide crystals, and store the...

Embodiment 2

[0046] Example 2 provides a photosensitive bioabsorbable polymer with in situ anti-cell adhesion function, the specific formula (100 grams) is as follows:

[0047] MC-modified three-arm photosensitive lactic acid oligomer (MC-3arms-LAO) 60g

[0048] NVP 32g

[0049] Irgacure 2959 8g

[0050] Wherein, the three-arm type photosensitive lactic acid oligomer (three-arm lactic acid oligomer with double bond) modified by FAME (monoethyl fumarate) is prepared by the following method:

[0051] Wherein, MC (methacryloyl chloride) modified three-arm type photosensitive lactic acid oligomer (three-arm type lactic acid oligomer with double bond) is lower than the three-arm type photosensitive lactic acid oligomer modified by FAME in Example 1. The only difference in the polymer preparation method is that the modifying agent in step (3) is replaced by methacryloyl chloride, and the remaining steps and parameters are the same.

[0052] The preparation method of the above-mentioned photos...

Embodiment 3

[0056] This embodiment 3 provides a photosensitive bioabsorbable polymer with in situ anti-cell adhesion function, and the specific formula (100 grams) is as follows:

[0057] AC-modified three-arm photosensitive lactic acid oligomer (AC-3arms-LAO) 55g

[0058] NVP 44g

[0059] Irgacure 2959 6g

[0060] Wherein, AC (acryloyl chloride) modified three-arm photosensitive lactic acid oligomer (three-arm lactic acid oligomer with double bond) and FAME modified three-arm photosensitive lactic acid oligomer in Example 1 The only difference in the preparation method is that the modifying agent in step (3) is replaced by acryloyl chloride, and the rest of the steps and parameters are the same.

[0061] (1) Add 150g of ethyl acetate and 100g of D-lactide successively in a round bottom flask, and continuously reflux and stir at 75°C until the L-lactide is completely dissolved; then the resulting solution is filtered under reduced pressure and the filtrate is collected; The filtrate wa...

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Abstract

The invention discloses a photosensitive bioabsorbable polymer with an in-situ cell adhesion resistance function and a preparation method of the photosensitive bioabsorbable polymer, and belongs to the technical field of biomedical polymer materials and photocuring. The photosensitive bioabsorbable polymer is prepared from the following raw materials: a multi-arm lactic acid oligomer with double bonds, vinyl pyrrolidone and a photoinitiator. The preparation method comprises the following steps: adding NVP with an in-situ anti-cell-adhesion function into a multi-arm lactic acid oligomer liquid with a double-bond structure in situ, and carrying out cross-linking curing molding on the components by virtue of an ultraviolet curing technology, so as to prepare the photosensitive bioabsorbable polymer with the in-situ anti-cell-adhesion function. The problems that in a traditional alteration technology, a drug sustained-release anti-cell hyperplasia coating is prone to stripping and drug burst release is caused can be effectively solved, and the preparation method has the advantages of being safe in preparation process, low in cost, free of solvent, high in curing speed and the like.

Description

technical field [0001] The invention relates to the fields of biomedical polymer material technology and photocuring technology, in particular to a photosensitive bioabsorbable polymer with in-situ anti-cell adhesion function and a preparation method thereof. Background technique [0002] Ultraviolet curing technology (UV technology) refers to adding a photoinitiator (or photosensitizer) to a specially formulated system (called a photocuring system) to generate activity after absorbing the high-intensity ultraviolet light generated in the photocuring equipment. Free radicals or cations, thereby initiating polymerization, crosslinking and grafting reactions, making it a technology that transforms from liquid to solid within a certain period of time. Because the technology has the advantages of fast curing, high production efficiency, energy saving, environmental protection, high quality, economy, and is applicable to various substrates, it has been widely used in aerospace, m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F290/06C08F226/10C08F2/48A61L31/04A61L31/14
CPCC08F290/061C08F2/48A61L31/048A61L31/148C08F226/10C08L51/08
Inventor 唐中岚兰小蓉王云兵
Owner SICHUAN UNIV
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