Prognostic scoring model of mixed cell type liver cancer and construction method thereof

A construction method and prognostic technology, applied in the field of prognostic scoring model of mixed cell type liver cancer, can solve the problems of the development of a prognosis prediction model without cHCC-CCA, the limitations of clinical decision-making and prognosis prediction of mixed cell type liver cancer patients, etc. Improved outcomes, better clinical decision-making, better predictive power

Pending Publication Date: 2021-07-23
ZHONGSHAN HOSPITAL FUDAN UNIV
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Problems solved by technology

However, most of these staging systems were established in the HCC population and thus have limitations in clinical decision-making and prognosis prediction for patients with mixed-cell HCC
Due to the rarity of cHCC-CCA, few prognostic prediction models specifically for cHCC-CCA have been developed

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  • Prognostic scoring model of mixed cell type liver cancer and construction method thereof
  • Prognostic scoring model of mixed cell type liver cancer and construction method thereof

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Embodiment

[0040] The method for constructing the prognostic scoring model of mixed cell type liver cancer in this embodiment comprises the following steps:

[0041] (1) Clinically, after the patients with mixed cell type liver cancer are identified through case studies, their laboratory test results including albumin, γ-glutamyl transpeptidase, carcinoembryonic antigen, carbohydrate antigen 19-9, and tumor Size, number, microvascular invasion and lymph node invasion.

[0042] (2) Using single factor analysis to screen the indicators related to the prognosis of patients with mixed cell type liver cancer, that is, P<0.1.

[0043] (3) Multivariate analysis was used in the screened indicators to obtain independent prognostic factors, ie P<0.05.

[0044] (4) Determine the score according to the scoring table and classify it into the corresponding stage. For example, stage A has the best prognosis with a predicted survival time of 59 months; stage B has a moderate prognosis with a predicted ...

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Abstract

The invention provides a prognostic scoring model of mixed cell type liver cancer and a construction method thereof, and the construction method comprises the following steps: collecting clinical pathological indexes related to survival of a mixed cell type liver cancer patient according to clinical cases, including albumin, gamma-glutamyltranspeptidase, carcino-embryonic antigen, carbohydrate antigen 19-9, tumor size, tumor quantity, microvessels and lymph nodes; analyzing and screening indexes related to prognosis of the mixed cell type liver cancer patient by adopting a single factor; further incorporating the selected indexes into multi-factor analysis, and obtaining independent prognosis factors related to patient survival; assigning each index and establishing a scoring table for prognosis prediction according to the risk ratio of multi-factor analysis; the AUC and C-index of the prognostic scoring model of the mixed cell type liver cancer reach 0.72 and are superior to those of other existing prognostic models, so that the prognostic scoring model of the mixed cell type liver cancer is high in prediction efficiency and can better guide clinical decisions and further improve prognosis of patients.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a prognostic scoring model for mixed cell type liver cancer (the prognostic scoring model is named PSM-CHCC, PSM is the acronym for prognostic score model, prognostic scoring model; CHCC is combined HCC, Mixed cell type liver cancer) and its construction method. Background technique [0002] Mixed cell carcinoma of the liver (cHCC-CCA), originating from the differentiation of hepatocytes and cholangiocytes, is a rare disease accounting for about 2-5% of primary liver cancers. cHCC-CCA was first characterized by Allen and Lisa 70 years ago, and due to its unique biology, pathology, and clinical behavior, cHCC-CCA has attracted increasing attention in recent years. [0003] Studies have shown that the clinicopathological features of cHCC-CCA are intermediate between those of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). Nevertheless, cHCC-CCA is heterogeneou...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/70G16H50/20
CPCG16H50/20G16H50/70
Inventor 殷欣张锋陆申新胡可舒
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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