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Risk assessment model for intestinal polyp and related system

A risk assessment model and technology of polyps, applied in the field of biomedicine, can solve the problems of few researches on molecular markers of intestinal polyps, and achieve the goal of disease and normal, high prediction accuracy, high diagnostic sensitivity and specificity Effect

Pending Publication Date: 2021-07-23
QINGDAO MEDINTELL BIOMEDICAL CO LTD
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  • Summary
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  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, most of the current research is on the molecular markers of colorectal cancer, but there are few studies on the molecular markers of intestinal polyps; moreover, intestinal polyps are precancerous lesions of colorectal cancer, and colorectal cancer is suitable for Molecular markers and risk models not necessarily applicable to intestinal polyps

Method used

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  • Risk assessment model for intestinal polyp and related system
  • Risk assessment model for intestinal polyp and related system
  • Risk assessment model for intestinal polyp and related system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0122] Example 1 Construction of risk assessment model for intestinal polyps

[0123] 1. Data source and acquisition

[0124] All the data for constructing the intestinal polyp risk assessment model were downloaded from the TCGA and NCBI-SRA databases. The expression files of colorectal cancer and adjacent cancer were downloaded from the TCGA database, and the raw data of intestinal polyps were downloaded from the NCBI-SRA database. A total of 443 samples of colorectal cancer cases, 31 samples of intestinal polyps, and 72 normal samples were selected from the retrieval, and a total of 546 sample data were used for further screening and quality control.

[0125] 2. Raw data processing

[0126] Use fastp software for joint processing and quality control to obtain cleandata. The steps include:

[0127] a. Joint treatment

[0128] Use the double-end sequence automatic detection mode of fastp software to process the adapter;

[0129] b. Data pruning and quality control

[0130...

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Abstract

The invention relates to a risk assessment model for intestinal polyp and a related system, the system is embedded with the risk assessment model for intestinal polyp developed by utilizing machine learning, and by receiving sequencing information from a subject, the disease risk of the subject is judged according to the risk assessment model, and suggestions are further provided for treatment.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a risk assessment model of intestinal polyps and a related system. Background technique [0002] Intestinal polyps refer to raised lesions on the mucosal surface in the intestinal lumen, mostly found in the rectum and sigmoid colon, and their incidence gradually increases with age, and they also have a certain tendency of malignant transformation. Risk factors for intestinal polyps include dietary factors, inflammatory stimuli, unhealthy living habits, and genetic factors. Some intestinal polyps have a certain tendency to become cancerous under the long-term stimulation of risk factors. Adenomatous polyps are a kind of precancerous lesions, especially adenomatous polyps larger than 2cm have a high chance of canceration; other polyps are generally considered to have a low chance of canceration. The development from benign intestinal polyps to malignant colorectal cancer is a multi-factor...

Claims

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Application Information

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IPC IPC(8): G06Q10/06G06K9/62G16H50/70G16B25/10G16B30/10
CPCG06Q10/0635G06Q10/0639G16H50/70G16B25/10G16B30/10G06F18/2135G06F18/214
Inventor 杨承刚李雨晨
Owner QINGDAO MEDINTELL BIOMEDICAL CO LTD
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