Intraoperative injury stimulation reactivity monitoring system and method based on electroencephalogram coupling relation

Abstract

The invention discloses an intra-operative injury stimulation reactivity monitoring system and method based on an electroencephalogram coupling relation. The method includes steps of acquiring multi-channel electroencephalogram data in an operation and taking the reaction condition of a patient after injury stimulation as a label; extracting intra-channel and inter-channel MI values from the preprocessed multi-channel electroencephalogram data; constructing a data set by using the in-channel and inter-channel features with labels, and dividing the data set into a training set and a test set; and training the random forest classifier by using the training set, and verifying and optimizing the trained random forest classifier by using the test set. An injury stimulation monitoring means based on autonomic nerves is easily influenced by drugs and external factors, while an injury stimulation monitoring means based on electroencephalogram nonlinear characteristics, such as an entropy index, introduces forehead myoelectric spectrum entropy, reduces the interpretability of the index and is easily interfered by muscle relaxant drugs. The adopted coupling phase amplitude mode is an inherent state under anesthesia, so that the sensitivity of indexes to electromyographic signals is reduced, and high specificity is achieved.

Description

technical field [0001] The invention relates to the field of intraoperative sedation and analgesia monitoring, in particular to a system and method for monitoring the responsiveness to noxious stimuli during an operation by using an electroencephalogram coupling relationship. Background technique [0002] Intraoperative anesthesia monitoring mainly includes two parts: sedation monitoring and analgesia monitoring. There are relatively effective clinical methods for sedation monitoring, but the means for analgesia monitoring are far from enough. The key to analgesic monitoring is the monitoring of reactivity to noxious stimuli during surgery. At present, there are two main methods for monitoring the reactivity to noxious stimuli: one is based on the activity of autonomic nerves, which monitors the physiological characteristics affected by the autonomic nerves, and this method is easily interfered by factors such as drugs, diseases, and the environment; the other is Based on E...

AI Technical Summary

Problems solved by technology

However, the relationship between frequency spectrum and noxious stimulus reactivity is not clear, the interpretability of nonlinear characteristics is not strong, and the evoked EEG needs to be superimposed multiple times and the anti-interference ability is weak, which restricts the monitoring method based on EEG.

[0003] Research on anesthesia consciousness has proved that the change of EEG coupling mode is one of the main effects of anesthetic drugs on the state of brain consciousness, but for the monitoring of noxious stimulus reactivity, there is currently a lack of monitoring of noxious stimulus reactivity based on EEG coupling relationship Methods

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