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Automatic measurement system and method for mechanical properties of cells

A technology of mechanical properties and measurement systems, applied in the direction of measuring devices, scientific instruments, instruments, etc., can solve the problems of low automation, low efficiency, cumbersome operation, etc., and achieve the effect of high automation, strong applicability, and simple operation

Pending Publication Date: 2021-07-09
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This kind of cell measurement method always has artificial mechanical operation, cumbersome operation, low degree of automation, long time-consuming, low efficiency, unable to obtain a large amount of data, and measurement data is not accurate

Method used

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  • Automatic measurement system and method for mechanical properties of cells
  • Automatic measurement system and method for mechanical properties of cells
  • Automatic measurement system and method for mechanical properties of cells

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Embodiment Construction

[0036] In order to enable those skilled in the art to better understand the technical solutions in the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described The embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0037] Such as Figure 1-Figure 4 As shown, an embodiment of the present invention provides an automatic measurement system for cell mechanical properties, including a microfluidic chip 1, an industrial computer 2, an image acquisition module 3, a first microfluidic pump 4, a second microfluidic pump 5 and a signal The generator 6, the...

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Abstract

The invention discloses an automatic measurement system and method for mechanical properties of cells, wherein the system comprises a micro-fluidic chip, an industrial personal computer, an image acquisition module, a first micro-flow pump, a second micro-flow pump and a signal generator, and the micro-fluidic chip is respectively connected with the first micro-flow pump, the second micro-flow pump and the signal generator; and the image acquisition module, the first micro-flow pump, the second micro-flow pump and the signal generator are all connected with the industrial personal computer. The invention further discloses an automatic measurement method for the mechanical properties of the cells. Hardware control is carried out through visual feedback, the cell length is recognized in combination with an image morphology algorithm, large-batch cell deformation quantity data is automatically measured, a cell mechanical database is established, cell mechanical characteristic analysis has statistical significance, operation is easy, the automation degree is high, the efficiency is high, external system integration can be carried out on various micro-fluidic chips or other similar devices integrating single cell capturing, stretching and releasing functions, the application range is wide, and the applicability is high.

Description

technical field [0001] The invention relates to a measuring device, in particular to an automatic measuring system and method for cell mechanical properties. Background technique [0002] Cell mechanics is a frontier field of biomechanics and an important part of tissue engineering. It involves the research on the mechanical properties of cells such as cell membrane and cytoskeleton deformation, elastic constants, viscoelasticity, and adhesion under mechanical loads, as well as the influence of mechanical factors on cell growth, development, maturation, proliferation, aging, and death. its mechanism research. Cell mechanics focuses on various types of cells in the human body, especially those related to the blood circulation system, human supporting movement system, and digestive system. [0003] Cells are the basic unit of the structure and function of organisms, and life activities are inseparable from cells. Therefore, in-depth research on cells is the key to uncovering...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/14
CPCG01N15/1404G01N15/1436G01N15/1484G01N2015/1006G01N2015/1493
Inventor 李志伟张星辰郑昕宇邹文婧杨馥与朱铭杰杨浩孙立宁
Owner SUZHOU UNIV
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