Glucocorticoid receptor antagonists for treatment of dementia
A technology of glucocorticoids and receptor antagonists, applied in the field of psychiatry, can solve the problems of reducing the speed of cognitive decline, dementia etiology and treatment inconsistency
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[0120] Example 1: Treatment of dementia with mifepristone
[0121] The following examples illustrate studies that demonstrated that the methods of the present invention are effective in the treatment of dementia.
[0122] Research Background
[0123] The study demonstrates that mifepristone, a glucocorticoid receptor (GR) antagonist given daily at doses of approximately 200 mg, is an effective treatment for slowing early cognitive decline in Alzheimer's disease.
[0124] patient choice
[0125] Patients in this study were diagnosed with early Alzheimer's disease using subjective and objective criteria, including those proposed by the National Institute of Neurological Diseases and Stroke (NINCDS) and DSM-IV described above. Mer's disease. All patients gave written consent to a protocol certified by the Human Subjects Committee at Stanford University Medical Center.
[0126] Only patients diagnosed with Alzheimer's dementia and confirmed by two psychiatrists were eligible t...
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