Short peptide for inhibiting Shiga toxin and application thereof
A Shiga toxin and short peptide technology, applied in the direction of peptides, anti-toxins, peptide/protein components, etc., to achieve stable binding state, excellent binding kinetics, and inhibition of toxicity
Active Publication Date: 2010-12-01
MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
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Problems solved by technology
Peptide inhibitors against Shiga toxins have not been reported so far
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Abstract
The invention discloses a making method of short peptide to inhibit shigellosis with amino acid as list 1, which is characterized by the following: adding chemical group, amino acid, peptide, protein, PEG, marked material to N and C ends to do kinds of chemical or biological decoration; optimizing the stability or other applying property and using scale; fitting for treat shigellosis, enterorrhagia escherichia coli O157 and cholera vibrio.
Description
A short peptide inhibiting Shiga toxin and its application technical field The present invention relates to a biological toxin inhibitor, in particular to a short peptide capable of inhibiting Shiga toxin, and also to a preparation method and application of the short peptide. Background technique Shiga toxin (Stx) is a kind of bacterial exotoxin with enterotoxicity, cytotoxicity and neurotoxicity produced by enteropathogenic bacteria, and is the most critical for emerging enteropathogens such as acute bacillary dysentery, cholera O139, O157:H7, etc. potent virulence factor. Clinically, it causes serious complications such as hemorrhagic colitis (hemorrhagiccolitis, HC), thrombotic thrombocytopenic purpura (TTP), and hemolytic uremia (hemolytic uremic syndrome, HUS) with a mortality rate as high as 80-90%. caused millions of deaths worldwide. At present, there are no specific and effective preventive products and emergency treatment drugs for Shiga toxin. Antibiotic tre...
Claims
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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/08A61K38/10A61P39/00
CPCY02A50/30
Inventor 王慧包士中荫俊史晶侯晓军蔡昆
Owner MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
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