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Chemicals delivery system and method

A chemical and chip technology, applied in biochemical equipment and methods, biochemical cleaning devices, biological material sampling methods, etc., can solve the problem of large structure size, large space occupation, increased laboratory construction costs and maintenance management costs, etc. problem, to achieve the effect of improving stability and reliability, realizing protection, and reducing difficulty

Pending Publication Date: 2021-06-18
SHEN ZHEN BIOROCKS BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during this automated operation, since the density of the vitrified liquid is higher than that of water, the eggs / embryos are usually suspended and easily moved with the flow of the liquid when immersed in the vitrified liquid. Ovum / embryo's own gravity causes it to sink to the bottom of the carrier, so there is a risk of accidentally flushing and aspiration of the egg / embryo when the robotic arm is delivering and aspirating chemicals through the straw
Therefore, in this method, by reducing the suction volume of the solution, more solution remains in the carrier to reduce the risk of eggs / embryos being accidentally sucked out, and too much solution remaining in the carrier will lead to an increase in thermal mass and affect Subsequent freezing speed, which adversely affects the vitrification process, and even leads to the failure of the egg / embryo freezing process
[0006] In addition, since the automated egg / embryo vitrification operation platform (Gavi) adopts a mechanical arm structure, the structure size of the entire platform is very large, which requires a large-scale laboratory for installation and use, and this increases the construction of the laboratory. Costs and maintenance management costs are not conducive to its promotion and use and reduce the cost of freezing eggs / embryos

Method used

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  • Chemicals delivery system and method
  • Chemicals delivery system and method
  • Chemicals delivery system and method

Examples

Experimental program
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Effect test

Embodiment 1

[0048] combine figure 1 As shown, in this embodiment, the chemical delivery system used in the glass freezing process for embryos includes a carrier 1 and a chip 2, wherein the carrier 1 is used to hold the embryos to be treated and related solutions, and the chip 2 It is used to carry different chemical solutions for sequential delivery.

[0049] combine figure 2 As shown, the carrier 1 is a strip structure, including a handle 11 , a sheet 12 and a groove 13 . Wherein, the groove 13 is located at the position near the front end in the sheet 12, and is used to hold the embryos to be processed and related solutions, and the size of the grooves 13 can be based on the number and size of the embryos to be processed, and the amount of solution used to hold them. Make adjustment settings. In this embodiment, the size of the groove is directly designed according to the residual amount of the solution during the subsequent freezing treatment, so as to accurately control the residu...

Embodiment 2

[0070] combine Figure 7 and Figure 8 As shown, in this embodiment, the chemical delivery system used in the glass freezing process for embryos also includes a carrier 1 and a chip 2 , and a base 3 is also provided. The base 3 is a channel steel structure, wherein the middle area of ​​the base 3 is used to support and fix the carrier 1, and the two side walls along its length direction can be used as guide rails 31 for providing support and support to the support plate 20 of the chip 2. Adsorption is fixed, and by changing the height of the guide rail 31, the positional relationship between the chip 2 and the upper surface of the carrier 1 can be adjusted, thereby ensuring effective contact between the gel and the solution in the groove.

[0071]Likewise, in other embodiments, a guide step may also be provided on the two guide rails respectively. In this way, when the chip is placed between the two guiding steps, the guiding step can also be used to form a guiding effect on...

Embodiment 3

[0078] combine Figure 9 As shown, in this embodiment, in addition to the carrier 1, the chip 2 and the substrate 3, the chemical delivery system used for the glass freezing process of the embryo is also provided with a direct support for the substrate 3. base 4, and a drive unit composed of a stepper motor 41, a screw mandrel 42 and a push rod 43 is installed on the base 4. Wherein, the base 3 is located on the base 4 and is kept parallel to the screw rod 42, and the push rod 43 is sleeved on the screw rod 42 and can move back and forth along the screw rod 42 under the drive of the stepping motor 41, while pushing the rod 43 It is fixedly connected with chip 2.

[0079] At this time, the stepper motor 41 drives the push rod 43 to reciprocate horizontally along the screw rod 42, which can drive the chip 2 to reciprocate in the horizontal direction relative to the carrier 1, thereby controlling the gel in different sections on the chip 2 to be sequentially aligned with the car...

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Abstract

The invention belongs to the technical field of chemicals delivery. In order to solve the problems of difficulty in delivery operation and poor stability of chemicals when the chemicals are delivered during ovum / embryo freezing treatment in the prior art, the invention discloses a chemicals delivery system and a method. The system comprises a carrier and a chip. A groove is formed in the carrier and is used for containing solution. An interval is arranged on the chip, and internally provided with chemicals to be delivered. The coverage area of the interval is larger than the opening area of the groove. The chip and the carrier can move relative to each other. The chemicals to be delivered located in the interval can make full-coverage contact with the solution in the groove, and forms free diffusion between the chip and the carrier. According to the present invention, when the chemicals are delivered during ovum / embryo freezing treatment, the delivery operation difficulty can be lowered, and the stability and reliability of the operation process are improved.

Description

technical field [0001] The invention belongs to the technical field of chemical delivery, and in particular relates to a chemical delivery system and method for chemical delivery to biological materials or solutions. Background technique [0002] The precise delivery of chemicals to biological materials or base solutions with which they will interact and react in specific ways is important in many applications and research. For example, during the freezing process of ovum / embryo, after taking out the ovum / embryo, it needs to be mixed with basic culture solution (Basic solution, BS), equilibrium solution (Equilibrium solution, ES) and vitrification solution (vitrification solution, VS) contact treatment and then put into liquid nitrogen for freezing treatment. [0003] During the contact treatment of eggs / embryos with different chemicals, it is necessary to accurately control the contact time of eggs / embryos with different chemicals according to the concentration of chemical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00C12M1/32
CPCC12M21/06C12M23/46C12M23/48C12M33/00
Inventor 陈昊楠舒怡玮
Owner SHEN ZHEN BIOROCKS BIOTECHNOLOGY CO LTD
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