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Application of miltefosine and pharmaceutically acceptable salt thereof in preparation of medicine for treating Alzheimer's disease

A technology for Alzheimer's disease and miltefosine, which is applied to the application field of miltefosine and its pharmaceutically acceptable salts in the preparation of medicines for treating Alzheimer's disease, and can solve the problems of memory, Cognitive dysfunction, etc.

Inactive Publication Date: 2021-05-18
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it has not been reported that it can improve the memory, cognitive dysfunction and anxiety state of 3xTg-AD model mice, thereby playing an anti-Alzheimer's disease (Alzheimer's disease, AD) effect

Method used

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  • Application of miltefosine and pharmaceutically acceptable salt thereof in preparation of medicine for treating Alzheimer's disease
  • Application of miltefosine and pharmaceutically acceptable salt thereof in preparation of medicine for treating Alzheimer's disease
  • Application of miltefosine and pharmaceutically acceptable salt thereof in preparation of medicine for treating Alzheimer's disease

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0018] Example 1: Miltefosine improves the memory, cognitive dysfunction and anxiety state of 3xTg-AD model mice in novel object recognition, Y-maze, elevated plus maze and Morris water maze behavioral experiments.

[0019] The present invention detects the effect of miltefosine on the improvement of memory, cognitive dysfunction and anxiety state of mice in 3xTg-AD model mice, and the experiment shows that miltefosine can significantly improve Memory, cognitive impairment, and anxiety states in behavioral tests of recognition, Y-maze, elevated plus maze, and Morris water maze.

[0020] 1. Experimental principle

[0021] 1) New object recognition experiment (New object recognition, NOR): a learning and memory test method established based on the principle that animals have a tendency to explore new objects, allowing mice to perform learning and memory tests in a free-moving state, more closely simulating humans learning and memory behavior.

[0022] 2) Y-maze test (Y-maze): ...

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Abstract

The invention discloses application of miltefosine and pharmaceutically acceptable salts thereof in preparation of drugs for treating neurodegenerative diseases related to memory, cognitive function and anxiety, including Alzheimer's disease. A large number of experimental screening results show that the miltefosine and the pharmaceutically acceptable salts thereof can improve memory and cognitive dysfunction and anxiety states of 3xTg-AD model mice in behavioral experiments of new object recognition, Y-maze, elevated plus maze and Morris water maze.

Description

technical field [0001] The present invention relates to the technical field of medicines, in particular to the application of miltefosine and its pharmaceutical composition in the preparation of medicines for treating Alzheimer's disease, more specifically, the present invention relates to miltefosine and its pharmaceutically acceptable The accepted salt or its pharmaceutical composition can improve the memory, cognitive dysfunction and anxiety state of 3xTg-AD model mice, and can be used in the preparation of drugs for treating neurodegenerative diseases such as Alzheimer's disease. Background technique [0002] Alzheimer's disease (Alzheimer's Disease, AD) is a progressive neurodegenerative disease, also known as senile dementia, is an age-related neurodegenerative disease. Clinical manifestations include memory impairment, aphasia, agnosia, impairment of visuospatial skills, executive dysfunction, and changes in personality and behavior. Currently known, the main patholo...

Claims

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Application Information

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IPC IPC(8): A61K31/661A61P25/28A61P25/22
CPCA61K31/661A61P25/28A61P25/22
Inventor 沈旭王佳颖沈星意吕建璐
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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