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Application of intestine-regulating decoction to preparation of medicine for treating Crohn's disease

A technology for Crohn's disease and bowel management, which is applied in the field of biomedicine and can solve the problems of excessive adverse reactions, high tolerance rate, and easy recurrence.

Active Publication Date: 2021-04-13
SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned drugs can take effect quickly in the treatment of Crohn's disease, they have the defects of easy recurrence, excessive adverse reactions and high tolerance rate

Method used

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  • Application of intestine-regulating decoction to preparation of medicine for treating Crohn's disease
  • Application of intestine-regulating decoction to preparation of medicine for treating Crohn's disease
  • Application of intestine-regulating decoction to preparation of medicine for treating Crohn's disease

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preparation example Construction

[0025] When the intestine-reducing soup base is used to prepare granules, the auxiliary materials are preferably sucrose powder and dextrin. The preparation method of the granule-form medicine for treating Crohn's disease is preferably: decocting the raw materials of Lichang Decoction to obtain a filtrate, refining the filtrate to obtain a clear ointment, mixing the clear ointment and auxiliary materials evenly, granulating and drying to obtain a granule. In the present invention, the decocting is preferably performed twice, and the time for each decoction is preferably 2 hours. The refinement preferably sequentially includes: concentrating the filtrate, extracting the supernatant, and concentrating the supernatant to obtain a clear paste. During the concentration, the present invention preferably concentrates the relative density of the filtrate to 1.25-1.30 (80° C.). The extraction supernatant is specifically preferably as follows: add 1500ml of ethanol to the concentrated ...

Embodiment 1

[0032] Codonopsis 30g, Stir-fried Atractylodes macrocephala 15g, Myrobalan 15g, Chishizhi 30g (fried), Sophora japonica 15g, Raw Puhuang 15g (fried), Bletilla striata 15g, Toon root bark 30g, Coix seed 30g, Panax notoginseng slices 10g, Xu Changqing 30g, licorice slices 10g.

[0033]Soak the above raw materials in 1225mL of distilled water for 30min, decoct with strong fire until boiling, then decoct with slow fire for 30-40min, filter out the filtrate; add 700mL of water to the medicinal dregs, repeat the above steps, decoct again, and filter. After combining the two filtrates, heat and stir until well mixed. Pipette 84 mL of the above Lichang Decoction into a 10 mL centrifuge tube, centrifuge at 12000 rpm / min at 4°C for 10 min, and then use a rotary evaporator to concentrate the solution to 0.55 g / mL, 1.1 g / mL and 2.2 g / mL respectively.

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Abstract

The invention relates to the field of biomedicine, in particular to application of an intestine-regulating decoction to preparation of a medicine for treating the Crohn's disease. The technical solution provided by the invention significantly improves symptoms including occult blood, hematochezia, body mass loss, disease activity index (DAI) score, pathological changes and the like brought by the Crohn's disease (CD), and new application is opened up for the intestine-regulating decoction.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of Lichang Decoction in the preparation of medicines for treating Crohn's disease. Background technique [0002] Crohn's disease is a chronic, relapsing inflammatory disease caused by many factors, and its onset is mostly related to factors such as genetic susceptibility, immune system damage, intestinal flora imbalance, environmental changes, and greater mental ups and downs . The main clinical manifestations of Crohn's disease are abdominal pain, diarrhea, abdominal mass, fistula formation, and perianal lesions, which may be accompanied by bloody stool and other symptoms. Since the exact etiology and pathogenesis of Crohn's disease have not yet been clarified, and it has the characteristics of recurrent attacks, long course of disease, and difficulty in recovery, it has become one of the common refractory diseases of the digestive system, and has a high cancer rate, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61K9/08A61K9/20A61K9/16A61P1/00A61P29/00A61K31/7016A61K33/26A61K35/644
CPCA61K36/344A61K36/284A61K36/185A61K36/8994A61K36/27A61K33/26A61K36/258A61K36/88A61K36/898A61K36/489A61K36/484A61K36/752A61K35/644A61K31/7016A61K36/52A61K9/0095A61K9/2068A61K9/1652A61K47/183A61K47/26A61K47/12A61P1/00A61P29/00A61K2300/00
Inventor 黄彬黄明河许艺飞郭绍举林保福罗爽
Owner SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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