System and method for determining lung health

A lung disease and cell technology, applied in blood/immune system cells, anti-animal/human immunoglobulin, anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, etc.

Pending Publication Date: 2021-02-26
生物阿非尼提科技公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although this technique is more sensitive than conventional cytology, its specificity is only about 50% (10)

Method used

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  • System and method for determining lung health
  • System and method for determining lung health
  • System and method for determining lung health

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0078] In addition, the following terms shall have the following definitions. It should be understood that for a specific term not defined below, the term shall have the meaning typically used by those of ordinary skill in the art in the context.

[0079] It should be noted that, as used herein and in the appended claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise.

[0080] The term "calibration" refers to setting the sensitivity of the machine against control reagents.

[0081] The term "compensation" refers to comparing a sample to a control to determine background.

[0082] The terms "isolated" or "isolated" refer to the selection of a subset of events for further analysis. An example of separation is the use of "gates" to exclude / include data during analysis.

[0083] The term "gate" refers to placing boundaries around populations of cells that share common characteristics (typically forward scatter, si...

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Abstract

Predicting the likelihood of lung disease in a subject, comprising labeling an ex-vivo sputum sample from a subject with one or more of the following: a first labeled probe that binds a biomarker expressed on a white blood cell population in the sample; a second labeled probe selected from the group consisting of: a granulocyte probe, a T-cell probe, a B-cell probe, or any combination thereof; a third labeled probe that binds a biomarker on a macrophage cell population; a fourth labeled probe that binds to a disease related cell in the sample; a fifth labeled probe that binds to a biomarker expressed on an epithelial cell population; and a sixth labeled probe that binds to a cell surface biomarker expressed on an epithelial cell population to obtain data comprising a mean fluorescent signature and detecting a profile based upon a presence or absence of labeled probes.

Description

[0001] References to related applications [0002] This application claims priority and benefit to U.S. Provisional Patent Application 62 / 657,584, filed April 13, 2018, entitled "System and Method for Determining Lung Health," the specification and claims of which are incorporated by reference combined here. [0003] Statement Regarding Federally Funded Research or Development [0004] Not applicable. [0005] Names of parties to the joint research agreement [0006] Not applicable. [0007] Incorporation by reference of material submitted on CD-ROM [0008] Not applicable. [0009] Statement Regarding Prior Publication by Inventor or Co-Inventor [0010] Not applicable. [0011] Copyrighted Materials [0012] Not applicable. Background technique [0013] Note that the following discussion refers to many documents by author and year of publication, some documents are not considered prior art to the present invention due to the most recent publication date. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/078C12N5/09G01N33/574G01N33/483G01N33/52G01N21/64C07K16/28C07K16/30
CPCG01N33/57423G01N2800/52G01N33/57492G01N2800/12G01N33/582G01N33/6893G01N2800/122G01N2800/60
Inventor 薇薇安·I·里贝尔
Owner 生物阿非尼提科技公司
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