Screening method of biomarker for predicting prognosis of esophageal squamous cell carcinoma

A biomarker, esophageal squamous cell carcinoma technology, applied in the field of biomarkers for predicting the prognosis of esophageal squamous cell carcinoma, can solve problems such as low repeatability, and achieve the effect of high accuracy and high reliability

Pending Publication Date: 2021-02-23
THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF SCI & TECH
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  • Abstract
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Problems solved by technology

[0004] In view of the molecular heterogeneity of tumors in the prior art, the differences in specimen sources, tissue processing, detection techniques, data analysis, etc., and the low reproducibility of the results of different clinical experiments, this application provides a method for predicting esophageal squamous cell carcinoma. Screening method for prognostic biomarkers, computer-readable storage medium, and biomarkers for predicting prognosis of esophageal squamous cell carcinoma

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  • Screening method of biomarker for predicting prognosis of esophageal squamous cell carcinoma
  • Screening method of biomarker for predicting prognosis of esophageal squamous cell carcinoma
  • Screening method of biomarker for predicting prognosis of esophageal squamous cell carcinoma

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Embodiment Construction

[0020] The following will clearly and completely describe the technical solutions in the embodiments of the application with reference to the drawings in the embodiments of the application. Apparently, the described embodiments are only some of the embodiments of the application, not all of them. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the scope of protection of this application.

[0021] In the description of this application, it should be noted that the orientation or positional relationship indicated by the terms "upper", "lower", "inner" and "outer" are based on the orientation or positional relationship shown in the drawings, and are only for It is convenient to describe the application and simplify the description, but not to indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific...

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Abstract

The invention relates to the technical field of biology, and particularly discloses a screening method of a biomarker for predicting esophageal squamous cell carcinoma prognosis. The method comprisesthe following steps: retrieving a biological information database according to identification information of esophageal squamous cell carcinoma so as to obtain a candidate molecules associated with esophageal squamous cell carcinoma; obtaining gene expression values of the a candidate molecules; constructing an interaction network of a candidate molecules according to the gene expression value; screening the plurality of candidate molecules for the first time based on an interaction network so as to filter part of the candidate molecules, and reserving b candidate molecules meeting a preset condition; based on the prognosis prediction model, carrying out second screening on the b candidate molecules reserved after the first screening to obtain c preferred molecules; and selecting the biomarker for predicting prognosis of esophageal squamous cell carcinoma from the c priority molecular sieves. By means of the mode, the credibility degree of the screening result is higher, and the accuracy of the screening result is higher.

Description

technical field [0001] The present application relates to the field of biotechnology, in particular to a screening method for biomarkers used to predict the prognosis of esophageal squamous cell carcinoma, a computer-readable storage medium, and a biomarker used to predict the prognosis of esophageal squamous cell carcinoma. Background technique [0002] Cancer is a disease that is extremely harmful to humans. According to relevant epidemiological data, there are about 11 million new cancers every year. Among many cancers, the incidence of esophageal cancer ranks eighth among all malignant tumors, and the death rate ranks sixth. About 45,000 people around the world suffer from this disease every year. Different from esophageal adenocarcinoma, which is mostly esophageal adenocarcinoma in western countries, esophageal squamous cell carcinoma (ESCC), hereinafter referred to as esophageal squamous cell carcinoma or ESCC, accounts for more than 95% of the overall incidence of eso...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B50/00G16B5/00G16B25/00
CPCG16B5/00G16B25/00G16B50/00
Inventor 齐义军李孟祥陈攀焦叶林刘轲冯笑山高社干
Owner THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF SCI & TECH
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