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Functionalized biological hybrid micro-nano motor and preparation method thereof

A bio-hybrid, micro-nano technology, applied in the field of material technology and micro-nano manufacturing, can solve the problems of inability to solve the core driving problem of synthetic micro-nano motors, underutilization of biological entity functions, etc., and achieve uniform size and rapid detection. , the effect of enhancing magnetic responsiveness and magnetic motion control

Inactive Publication Date: 2021-02-19
SOUTHWEAT UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the functions of these biological entities are underutilized
For example, relying solely on the method of cell membrane-coated micro-nano motors cannot solve the core driving problem of synthesizing micro-nano motors
Biohybrid micro-nanomotors with easy observation and consistent controllable actuation still face the challenges of uniform preparation and controllable actuation

Method used

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  • Functionalized biological hybrid micro-nano motor and preparation method thereof
  • Functionalized biological hybrid micro-nano motor and preparation method thereof
  • Functionalized biological hybrid micro-nano motor and preparation method thereof

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preparation example Construction

[0030] Aiming at the problems described above in the background technology, the present invention provides a functionalized biohybrid micro-nano motor and a preparation method thereof.

[0031] The functionalized biohybrid micro-nanomotor includes a bioentity inner core, a magnetic nanoparticle coating and a probe layer. The inner core of biological entities can be natural plant seeds, fungal spores, pollen, etc., which have unique and complex three-dimensional structures and can be cultivated or obtained in large quantities. On the surface of the inner core of the biological entity is a magnetic nanoparticle coating for micro-nanomotor drive and manipulation, which can be self-assembled by chemisorption-deposited magnetic nanoparticles. On the surface of the inner core of the biological entity wrapped by the magnetic nano-coating, there are probes immobilized by self-assembled functional groups, which include carbon dots with fluorescence emission and response capabilities an...

Embodiment

[0036] Taking the oligosaccharide-functionalized spore-based micro-nanomotor as an example, the functionalized biohybrid micro-nanomotor and its preparation method are described in detail.

[0037] Described preparation method comprises:

[0038] Step 1. Pretreatment of Ganoderma lucidum or Lycopodium spores, followed by ultrasonic treatment in 200mL absolute ethanol for 30min, ultrasonic treatment in 200mL deionized water for 10min and washing with deionized water several times to remove impurities on the outer membrane and inner core, Freeze-dried for later use.

[0039] Step 2. Ultrasonic disperse the spores pretreated in step 1 into 60 mL of deionized water, and stir for 5 min to form a brown suspension with evenly dispersed spores. Then FeSO was added to the above suspension 4 After stirring for 20 min, 20 mL of ammonia water (25%-27 wt %) was added dropwise, and the dropping time was controlled within 10 min. Following sealing and further stirring for 2 h, the black m...

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Abstract

The invention belongs to the field of material technology and micro-nano manufacturing, and relates to a functionalized biological hybrid micro-nano motor and a preparation method thereof. The functionalized biological hybrid micro-nano motor comprises a biological entity inner core, a magnetic nanoparticle coating and a probe layer. According to the invention, fungal spores, pollen and micro / nano-scale plant seeds are selected as the inner core, so that the inner core is easy to obtain or massively culture, and the material is uniform in size and easy to control; and the inner core and the nano-particles are hybridized through a step-by-step coating method, and a probe is loaded on the surface of the nano-coating. The functionalized biological hybrid micro-nano motor can actively move under accurate control, is very easy to observe, and overcomes the defects in the prior art.

Description

technical field [0001] The invention belongs to the field of material technology and micro-nano manufacturing, and relates to a functional biohybrid micro-nano motor and a preparation method thereof. Background technique [0002] Micro-nano motors (also known as micro-nano robots) realize autonomous and continuous motion in three-dimensional space by converting external energy (light, electricity, magnetism, heat, chemical energy, etc.) Operation tasks. Its autonomous continuous motion in different liquid environments can lead to both microscale eddy currents and surface dynamic chemistry. The synergy of these two effects can not only realize the microscopic mixing of solutions, accelerate the diffusion of solute molecules, and increase the rate and yield of chemical reactions, but also enable micro-nano motors to participate in various dynamic reactions at the same time as dynamic active reactors, improving the interaction between functional molecules and target molecules....

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/65G01N21/64
CPCC09K11/025C09K11/65G01N21/6428G01N2021/6432
Inventor 张亚斌肖林李国强蔡勇杨益
Owner SOUTHWEAT UNIV OF SCI & TECH
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