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Anti-wrinkle composition and anti-wrinkle cream

A composition and anti-wrinkle cream technology, which is applied in the direction of drug combination, plant raw materials, plant/algae/fungus/moss components, etc., can solve the problem of limited anti-wrinkle function, achieve the effect of small molecular weight, improve wrinkles, and clear effect

Active Publication Date: 2021-02-12
瑞资兰(杭州)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main purpose of the present invention is to provide an anti-wrinkle composition and anti-wrinkle cream, to solve the problem of limited anti-wrinkle function of anti-oxidation technology in the prior art

Method used

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  • Anti-wrinkle composition and anti-wrinkle cream
  • Anti-wrinkle composition and anti-wrinkle cream
  • Anti-wrinkle composition and anti-wrinkle cream

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Experimental program
Comparison scheme
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preparation example Construction

[0031] In order to facilitate the preparation of the anti-wrinkle composition of the present application, and the stable discovery of the anti-wrinkle effect of the anti-wrinkle composition of the present application, some embodiments of the present application also provide a preparation method of the water extract of Kumquat, which includes: using water to The kumquat peel is heated and refluxed to obtain a water extract; the water extract is subjected to solid-liquid separation and rotary evaporation to obtain a kumquat water extract, and the volume of the kumquat water extract is 1 / 8 to 1% of the volume of the water extract. / 3, the weight ratio of preferred water and kumquat peel is 7~14: 1, and the time of extraction under reflux preferably is 1~5h. The kumquat water extract obtained by other extraction methods in the prior art also has anti-wrinkle effect to a certain extent, but the above-mentioned preparation method is simple and easy to operate, and the obtained kumqua...

Embodiment 1

[0041] 1. Raw material preparation

[0042] Kumquat Alcoholic Extract: Use 500mL 20% ethanol solution to heat and reflux extract 50g of fresh Kumquat peel for 3 times, each time for 1h, combine the extracts for 3 times, and rotary evaporate after suction filtration to obtain about 50ml of alcohol extract .

[0043] Kumquat water extract: Use 500mL of water to heat and reflux extract 50g of fresh kumquat peel for 3 times, each time for 1h, combine the extracts from 3 times, filter and rotary evaporate to obtain about 50ml of water extract.

[0044] Polygonatum extract: Use 500mL of water to extract 20g of Cornus officinalis at 50-90°C for 50-90min to obtain Polygonatum extract;

[0045] Cornus officinalis extract: Use 500mL of water to extract 20g of cornus officinalis at 50-90°C for 50-90min to obtain the cornus officinalis extract.

[0046] The above-mentioned Polygonatum extract, Cornus officinalis extract and Kumquat water extract were mixed with a weight ratio of 5:5:1 t...

Embodiment 2

[0100] Example 2 Excipient screening

[0101] Glyceryl monostearate, stearic acid, white petrolatum, and liquid paraffin were weighed and heated to melt, and kept at 86° C. as the oil phase. Weigh glycerin, triethanolamine, sodium lauryl sulfate and ultrapure water, heat and dissolve to 86°C, slowly add the oil phase, stir evenly, add kumquat extract, stir evenly until condensed, and conduct a preliminary experiment.

[0102] According to the pre-test results, the auxiliary material has a good appearance, uniform and fine, no grainy feeling, good spreadability, and easy to clean. And through the test of volunteers, no allergic phenomenon occurred, indicating that the excipient is feasible, and the next step of the experiment can be carried out.

[0103] Screening of the Best Formulation of Excipients

[0104] Experimental research was carried out according to the conventional emulsion configuration method. Stearic acid, glyceryl monostearate, liquid paraffin, and white vasel...

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Abstract

The invention provides an anti-wrinkle composition and an anti-wrinkle cream. The anti-wrinkle composition is prepared from rhizoma polygonati extract, fructus corni extract and kumquat extract according to the weight ratio of (5 to 7) to (3 to 6) to 1. The anti-wrinkle composition comprises the rhizoma polygonati extract, the cornus officinalis extract and the kumquat extract, and can block a voltage-dependent Nav1.4 channel on a cell membrane in muscle, so that release of ions is influenced, the action target is clear, and the effect is also clear; and due to the use of the rhizoma polygonati extract and the cornus officinalis extract, the absorption of the kumquat extract is promoted. The compounds in the extracts are small in molecular weight and easy to penetrate through the skin, theeffect of remarkably relaxing excessively single muscle tension can be achieved, and generated wrinkles can also be relieved and improved.

Description

technical field [0001] The invention relates to the technical field of anti-wrinkle, in particular to an anti-wrinkle composition and anti-wrinkle cream. Background technique [0002] With age, the body's metabolism begins to slow down, water and subcutaneous fat decrease, elastic fibers gradually become thicker, the skin becomes wrinkled and its luster fades. Skin aging is a prominent manifestation of the aging of the whole body, especially facial skin aging. The number of fibroblasts in the human body gradually decreases, and the collagen and elastin secreted by them are also gradually reduced and broken due to oxidation, supporting the epidermis. The effect disappears, resulting in uneven collapse, the dermis begins to thin, skin elasticity becomes poor, and wrinkles begin to gradually appear. Although skin aging is an irreversible physiological phenomenon, its process can be delayed or slowed down. For facial wrinkles, the most commonly used anti-wrinkle cosmetics. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9794A61K8/9789A61K36/8969A61Q19/08A61Q19/00A61P17/18A61P17/16
CPCA61K8/9794A61K8/9789A61K36/8969A61K36/40A61K36/75A61Q19/00A61Q19/08A61P17/16A61P17/18A61K2800/805A61K2236/331A61K2236/333A61K2800/5922A61K2300/00
Inventor 潘兰英潘宏川
Owner 瑞资兰(杭州)生物科技有限公司
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