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Active agent, oxygen-free hyaluronic acid production method and product thereof

A production method, hyaluronic acid technology, applied in the direction of microorganism-based methods, biochemical equipment and methods, microorganisms, etc., can solve the problems of hyaluronic acid products' own quality damage, large residual amount of ethylene oxide, etc., and achieve high safety effects

Active Publication Date: 2021-02-09
桂林恒保健康防护有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, if hyaluronic acid products are sterilized, it is necessary to increase the dose of ethylene oxide or radiation. As a result, the residual amount of ethylene oxide is often large, or the quality of hyaluronic acid products is damaged to a certain extent.

Method used

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  • Active agent, oxygen-free hyaluronic acid production method and product thereof
  • Active agent, oxygen-free hyaluronic acid production method and product thereof

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Embodiment Construction

[0033] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only for illustrating the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all conventional products that could be purchased from the market.

[0034] The present invention will be further explained below in combination with specific embodiments.

[0035] This embodiment firstly provides an active agent, which is mainly used for hyaluronic acid cross-linking treatment, and its components include: 4-6 parts by mass of 3-(trihydroxy)silylpropyl dimethyl octadecadeca Alkyl ammonium chloride, 0.03-...

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Abstract

The invention provides an active agent, a hyaluronic acid production method and a product thereof, the active agent is used for cross-linking treatment of hyaluronic acid, and the active agent comprises the following components in parts by mass: 4-6 parts of 3- (trihydroxy) silyl propyl dimethyl octadecyl ammonium chloride, 0.03-0.07 part of chloropropyl silane and 90-97 parts of deionized water.In the hyaluronic acid cross-linking link, the active agent is added into a hyaluronic acid fermentation solution, hydroxyl silicon molecules in the active agent and hyaluronic acid small molecules are fully cross-linked, and modification and immobilization are carried out in a covalent bond mode to form a new group. Experiments prove that the group has positive charge characteristics of cations,good deoxidation and antioxidant effects and a good physical sterilization effect.

Description

technical field [0001] The invention relates to the technical field of hyaluronic acid and its products, in particular to an active agent, an oxygen-free hyaluronic acid production method and its products. Background technique [0002] At present, hyaluronic acid, as a high-quality elastic material, has been widely used in the fields of condoms, condoms, and medical gloves. Most of its products are medical devices above grade 2. After the finished product, it needs to be sterilized by means of ethylene oxide and radiation. Treatment, and then control the germs within a certain number. However, if hyaluronic acid products are sterilized, it is necessary to increase the dose of ethylene oxide or radiation. As a result, the residual amount of ethylene oxide is often large, or the quality of hyaluronic acid products is damaged to a certain extent. [0003] Therefore, how to realize hyaluronic acid products in the case of conventional disinfection doses or methods, greatly reduc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08K5/544C08K5/54C08L5/08C08J3/24C12P19/26C12R1/125C12R1/46
CPCC08K5/544C08K5/5406C08J3/24A61L31/042A61L31/14C12P19/26C08J2305/08C08L5/08
Inventor 胡智强
Owner 桂林恒保健康防护有限公司
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